Unexpected dimerization of a nitrobenzyl chloride under basic conditions

Unexpected dimerization of a nitrobenzyl chloride under basic conditions

Santos, Giovanna C.; Macedo, Jéssica B.; Lopes, Marcela S.; Pádua, Rodrigo M. de; Oliveira, Renata B.

Abstract:

The 4-(chloromethyl)-3-nitro-N-(2-hydroxyethyl)- benzamide (1), previously synthesized by our research group, is a promising antitumor agent whose activity in vitro and in vivo has recently been investigated. Forced degradation studies are an important part of drug development process, which allows to identify the degradation products and to determine the intrinsic stability of the molecule. In this work, we describe the results of degradation studies of 1 under hydrolysis conditions.

The 4-(chloromethyl)-3-nitro-N-(2-hydroxyethyl)- benzamide (1), previously synthesized by our research group, is a promising antitumor agent whose activity in vitro and in vivo has recently been investigated. Forced degradation studies are an important part of drug development process, which allows to identify the degradation products and to determine the intrinsic stability of the molecule. In this work, we describe the results of degradation studies of 1 under hydrolysis conditions.

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DOI: 10.5151/chempro-15bmos-BMOS2013_201381974519

Referências bibliográficas

• [1] 1Oliveira, R. B. et al. PCT 003563 A1, 2012.

Como citar:

Santos, Giovanna C.; Macedo, Jéssica B.; Lopes, Marcela S.; Pádua, Rodrigo M. de; Oliveira, Renata B.; "Unexpected dimerization of a nitrobenzyl chloride under basic conditions", p-49-49. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201381974519