Towards the synthesis of 27-Deoxylyngbyabellin A analogues as potential chemotherapeutics.

Towards the synthesis of 27-Deoxylyngbyabellin A analogues as potential chemotherapeutics.

Scarone, Laura; Sandin, Leonardo; Serra., Gloria

Abstract:

Natural products play an important role in drug development, particularly in anticancer, antibiotics and antiparasitics drugs. Marine cyanobacteria have been attracting increasing attention in drug discovery due to their structurally novel bioactive secondary metabolites. These natural products are predominantly modified peptides and depsipeptides, many of which happen to be cyclic. 27-Deoxylyngbyabellin A (1, figure 1), which was isolated from the cyanobacteria Lyngbya bouillonii, showed moderate cytotoxicity toward cancer cell lines HT29 and HeLa. As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we are interested in the preparation of depsipeptides analogues of type 2. Herein, we presents the synthesis of fragment C4- C15 of depsipeptide of type 2 with X= O and R1= CH(CH3)2.

Natural products play an important role in drug development, particularly in anticancer, antibiotics and antiparasitics drugs. Marine cyanobacteria have been attracting increasing attention in drug discovery due to their structurally novel bioactive secondary metabolites. These natural products are predominantly modified peptides and depsipeptides, many of which happen to be cyclic. 27-Deoxylyngbyabellin A (1, figure 1), which was isolated from the cyanobacteria Lyngbya bouillonii, showed moderate cytotoxicity toward cancer cell lines HT29 and HeLa. As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we are interested in the preparation of depsipeptides analogues of type 2. Herein, we presents the synthesis of fragment C4- C15 of depsipeptide of type 2 with X= O and R1= CH(CH3)2.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013813144948

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Como citar:

Scarone, Laura; Sandin, Leonardo; Serra., Gloria; "Towards the synthesis of 27-Deoxylyngbyabellin A analogues as potential chemotherapeutics.", p-151-151. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013813144948