Total Synthesis of Isoellipticine

Total Synthesis of Isoellipticine

Naciuk, Fabrício Fredo; Malanzuk, Rebeca; Fontoura, Luiz Antonio Mazzini; Miranda, Paulo C. M. L.

Abstract:

The ellipticine (1), a member of pyridocarbazole family, was firstly isolated at the end of 50’s from the leaves of Ochrosia elliptica. This alkaloid aroused interest in the pharmacologic area due its unique antitumor and anticancer properties. More recently, studies indicate that this compound and its derivatives also show activity against HIV. The isoellilpticine (2), a non-natural isomer of ellipticine (1), exhibits similar biological properties, however its preparation has been little explored.

The ellipticine (1), a member of pyridocarbazole family, was firstly isolated at the end of 50’s from the leaves of Ochrosia elliptica. This alkaloid aroused interest in the pharmacologic area due its unique antitumor and anticancer properties. More recently, studies indicate that this compound and its derivatives also show activity against HIV. The isoellilpticine (2), a non-natural isomer of ellipticine (1), exhibits similar biological properties, however its preparation has been little explored.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013913103848

Referências bibliográficas

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Como citar:

Naciuk, Fabrício Fredo; Malanzuk, Rebeca; Fontoura, Luiz Antonio Mazzini; Miranda, Paulo C. M. L.; "Total Synthesis of Isoellipticine", p-222-222. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013913103848