THE REACTION OF L-HISTIDINE WITH ZIRCONIUM(IV) OXYNITRATE HYDRATE

THE REACTION OF L-HISTIDINE WITH ZIRCONIUM(IV) OXYNITRATE HYDRATE

de Menezes, A. S.; Melo, E. B.

Abstract:

The role of L-histidine in the biological activity of natural peptides is being studied for several years. Due to the presence of imidazole ring, the histidine presents a high affinity for metal ions and these ions play a role in several different biological processes. Histidine has three coordination sites and might act either as a monodentate, bidentate or tridentate ligand. In this work the L-histidine was mixed to zirconium(IV) oxynitrate hydrate (ZrO(NO3)2.xH2O) to produce the complexation of the L-histidine with the ZrO2+ ion. For that, 1 mol of zirconium(IV) oxynitrate hydrate was added to an aqueous solution containing 2 mols of L-Histidine. However, the solution became a white hydrogel and that was an unexpect result for us at that time. Then, the hydrogel solution was centrifuged to separate the gel from the solution. The gel was dried and submitted to powder X-ray diffraction measurements that showed an amorphous pattern but it can be identified as zirconium hydroxide (ZrO(OH)2). The heating of zirconium hydroxide up to 600oC produced nanocrystalline tetragonal and monoclinic ZrO2, being the tetragonal the higher amount phase. To know what is left in the solution, it was placed at rest at a temperature of 30oC to promote the evaporation of the water and to crystalize the solute. The obtained polycrystalline material was submitted to powder X-ray diffraction measurements but the obtained pattern was not indexed in comparison with the patterns of the ICDD and CCDC structural data banks.

The role of L-histidine in the biological activity of natural peptides is being studied for several years. Due to the presence of imidazole ring, the histidine presents a high affinity for metal ions and these ions play a role in several different biological processes. Histidine has three coordination sites and might act either as a monodentate, bidentate or tridentate ligand. In this work the L-histidine was mixed to zirconium(IV) oxynitrate hydrate (ZrO(NO3)2.xH2O) to produce the complexation of the L-histidine with the ZrO2+ ion. For that, 1 mol of zirconium(IV) oxynitrate hydrate was added to an aqueous solution containing 2 mols of L-Histidine. However, the solution became a white hydrogel and that was an unexpect result for us at that time. Then, the hydrogel solution was centrifuged to separate the gel from the solution. The gel was dried and submitted to powder X-ray diffraction measurements that showed an amorphous pattern but it can be identified as zirconium hydroxide (ZrO(OH)2). The heating of zirconium hydroxide up to 600oC produced nanocrystalline tetragonal and monoclinic ZrO2, being the tetragonal the higher amount phase. To know what is left in the solution, it was placed at rest at a temperature of 30oC to promote the evaporation of the water and to crystalize the solute. The obtained polycrystalline material was submitted to powder X-ray diffraction measurements but the obtained pattern was not indexed in comparison with the patterns of the ICDD and CCDC structural data banks.

Palavras-chave:

DOI: 10.5151/phypro-sic100-057

Como citar:

de Menezes, A. S.; Melo, E. B.; "THE REACTION OF L-HISTIDINE WITH ZIRCONIUM(IV) OXYNITRATE HYDRATE", p-57-57. In: Proceedings of the International Symposium on Crystallography [Blucher Physics Proceedings, v.1, n.3]. São Paulo: Blucher, 2015.
ISSN 23582359, DOI 10.5151/phypro-sic100-057