Abstract:

Aza-heterocyclic compounds, such as pyrazoles and pyridazinones, have become increasingly important because they have proven to be extremely bioactive moieties. The synthesis of nitrogen-containing heterocyclic compounds has been well explored by reacting of blocks precursors enaminodiketones with N-(C)n-N dinucleophiles. Data from the literature have demonstrated an efficient method for obtaining a series of enaminodiketones from C-acylation of enaminoketones with ethyl oxalyl chloride. The reaction of these precursors with N-N dinucleophiles was shown to be highly attractive for the synthesis of multifunctionalized pyrazoles and other aza-heterocyclic. Thus, considering the importance of nitrogen-containing heterocyclic compounds, the aim of this work, is to report synthetic application to obtain pyrazole multifunctionalized and pyrazolopyridazinones from cyclocondensation reaction of enaminodiketone (1) block precursor with hydrazines.