Synthesis of two new series of 7-aminocarbohydrateisoquinoline- 5,8-dione derivatives

Synthesis of two new series of 7-aminocarbohydrateisoquinoline- 5,8-dione derivatives

Silva, Wanderson A. da; Santos, Angela Cristina P. B. dos; Ferreira, Vitor F.; Montenegro, Raquel C.; Campos, Vinícius R.; Souza, Maria C. B. V. de; Cunha, Anna C.

Abstract:

Several natural compounds containing quinone and carbohydrate moieties possess significant antibiotic and antitumor activities. In this context, the synthesis of carbohydratequinone conjugates is currently an important field of pharmacy and chemistry. Herein, we report the synthesis and in vitro antitumor activity evaluation of two homologous series of sugar-based quinones 1a–c and 2a-c (Scheme).

Several natural compounds containing quinone and carbohydrate moieties possess significant antibiotic and antitumor activities. In this context, the synthesis of carbohydratequinone conjugates is currently an important field of pharmacy and chemistry. Herein, we report the synthesis and in vitro antitumor activity evaluation of two homologous series of sugar-based quinones 1a–c and 2a-c (Scheme).

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013619112621

Referências bibliográficas

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• [3] 2Campos, V. R.; Santos, E. A.; Ferreira, V. F.; Montenegro, R. C.;
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• [5] Regufe, A. k. P.; Jordão, A. K.; Pinto, A. C.; Resende, J. A. L. C.;
• [6] Cunha, A. C., rsc adv, 2012, 2, 11438.
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Como citar:

Silva, Wanderson A. da; Santos, Angela Cristina P. B. dos; Ferreira, Vitor F.; Montenegro, Raquel C.; Campos, Vinícius R.; Souza, Maria C. B. V. de; Cunha, Anna C.; "Synthesis of two new series of 7-aminocarbohydrateisoquinoline- 5,8-dione derivatives", p-145-145. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013619112621