Synthesis of triterpenes and steroids derivatives as potential anti- HIV and cancer compounds.

Synthesis of triterpenes and steroids derivatives as potential anti- HIV and cancer compounds.

Kuliakita*, Maria Candeia; Victor*, Maurício Moraes; David*, Jorge Mauricio

Abstract:

The Bevirimat®1 is a betulinic acid derivative (Figure 1) used in treatment of HIV, and melanoma, isthe first drugin the class of anti retrovirals that hampers the maturation of AIDS. This being derived from a pentacyclic triterpene type lupine other triterpene derivatives have been synthesized with the similarity of this intuition to increase lipophilicity and improve the biological activity of these compounds.

The Bevirimat®1 is a betulinic acid derivative (Figure 1) used in treatment of HIV, and melanoma, isthe first drugin the class of anti retrovirals that hampers the maturation of AIDS. This being derived from a pentacyclic triterpene type lupine other triterpene derivatives have been synthesized with the similarity of this intuition to increase lipophilicity and improve the biological activity of these compounds.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915204019

Referências bibliográficas

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Como citar:

Kuliakita*, Maria Candeia; Victor*, Maurício Moraes; David*, Jorge Mauricio; "Synthesis of triterpenes and steroids derivatives as potential anti- HIV and cancer compounds.", p-274-274. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915204019