Synthesis of the C10−C22 Fragment of Marinisporolide A

Synthesis of the C10−C22 Fragment of Marinisporolide A

Júnior, Emílio Carlos de Lucca; Dias, Luiz Carlos

Abstract:

Marinisporolide A (1) is an oxopolyene macrolide isolated in 2009 from the saline culture of the marine actinomycete Marinispora, strain CNQ-140 (Figure 1). The structure of marinisporolide A (1) consists of a total of 11 stereogenic centers within a 34- membered macrolide, containing a bicyclic spiro-bistetrahydropyran ketal and a conjugated pentaene. This work aimed to the synthesis of C10−C22 fragment of marinisporolide A.

Marinisporolide A (1) is an oxopolyene macrolide isolated in 2009 from the saline culture of the marine actinomycete Marinispora, strain CNQ-140 (Figure 1). The structure of marinisporolide A (1) consists of a total of 11 stereogenic centers within a 34- membered macrolide, containing a bicyclic spiro-bistetrahydropyran ketal and a conjugated pentaene. This work aimed to the synthesis of C10−C22 fragment of marinisporolide A.

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DOI: 10.5151/chempro-15bmos-BMOS2013_201382094824

Referências bibliográficas

• [1] 1 Kwon, H. C.; Kauffman, C. A.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2009, 74, 675.
• [2] 2 Dias, L. C.; Polo, E. C.; de Lucca Jr., E. C.; Ferreira, M. A. B. In Modern Methods in Stereoselective Aldol Reactions, vol. 1; Mahrwald, R., ed.; Wiley-VCH Verlag: Weinheim, Germany, 2013.

Como citar:

Júnior, Emílio Carlos de Lucca; Dias, Luiz Carlos; "Synthesis of the C10−C22 Fragment of Marinisporolide A", p-57-57. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201382094824