Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of Substituted Pyrazolones from Morita-Baylis-Hillman Adducts

Coelho, Fernando ; Zeoly, Lucas A. ; Barcelos, Rosimeire C. ; Jr., Manoel T. Rodrigues ; Martins, Lucimara J. ;

Abstract:

The pyrazolone moiety has been gaining attention because of its biological importance. This structure is present in some useful analgesic, antipyretic and anti-inflammatory drugs, namely metamizole, phenazone, propyphenazone and ampyrone. Therefore, we have focused our attention in the synthesis of this class of molecules using the classical 1,3-dicarbonyl compounds approach, which were obtained from Morita-Baylis-Hillman adducts.

Abstract:

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Palavras-chave: Morita-Baylis-Hillman, Heterocycles, Pyrazolones,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391521329

Referências bibliográficas
  • [1] 1 Gunasekaran, P. et al. Eur. J. Med. Chem. 2011, 46, 4530.
  • [2] 2 Coelho, F. et al. Tetrahedron, 2002, 7437.
  • [3] 3 Santos, M. S.; Coelho, F. RSC Advances, 2012, 2, 3237.
  • [4] 4 Pirovani, R. V.; Ferreira, B. R. V.; Coelho, F. Synlett, 2009, 2333.
Como citar:

Coelho, Fernando; Zeoly, Lucas A.; Barcelos, Rosimeire C.; Jr., Manoel T. Rodrigues; Martins, Lucimara J.; "Synthesis of Substituted Pyrazolones from Morita-Baylis-Hillman Adducts", p. 97 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391521329

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