Synthesis of Substituted Pyrazolones from Morita-Baylis-Hillman Adducts

Synthesis of Substituted Pyrazolones from Morita-Baylis-Hillman Adducts

Zeoly, Lucas A.; Barcelos, Rosimeire C.; Jr., Manoel T. Rodrigues; Martins, Lucimara J.; Coelho, Fernando

Abstract:

The pyrazolone moiety has been gaining attention because of its biological importance. This structure is present in some useful analgesic, antipyretic and anti-inflammatory drugs, namely metamizole, phenazone, propyphenazone and ampyrone. Therefore, we have focused our attention in the synthesis of this class of molecules using the classical 1,3-dicarbonyl compounds approach, which were obtained from Morita-Baylis-Hillman adducts.

The pyrazolone moiety has been gaining attention because of its biological importance. This structure is present in some useful analgesic, antipyretic and anti-inflammatory drugs, namely metamizole, phenazone, propyphenazone and ampyrone. Therefore, we have focused our attention in the synthesis of this class of molecules using the classical 1,3-dicarbonyl compounds approach, which were obtained from Morita-Baylis-Hillman adducts.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391521329

Referências bibliográficas

• [1] 1 Gunasekaran, P. et al. Eur. J. Med. Chem. 2011, 46, 4530.
• [2] 2 Coelho, F. et al. Tetrahedron, 2002, 7437.
• [3] 3 Santos, M. S.; Coelho, F. RSC Advances, 2012, 2, 3237.
• [4] 4 Pirovani, R. V.; Ferreira, B. R. V.; Coelho, F. Synlett, 2009, 2333.

Como citar:

Zeoly, Lucas A.; Barcelos, Rosimeire C.; Jr., Manoel T. Rodrigues; Martins, Lucimara J.; Coelho, Fernando; "Synthesis of Substituted Pyrazolones from Morita-Baylis-Hillman Adducts", p-97-97. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391521329