Synthesis of some 1,2,3-triazole-chalcones as potential anticancer agents

Synthesis of some 1,2,3-triazole-chalcones as potential anticancer agents

Pessôa, Jaqueline C.; Oliveira, Pãmella C. O. de; Fonseca, Meliza J. da C.; Pinheiro, Sergio; Muri, Estela M. F.; Dias, Ayres G.; Costa4, Paulo R. R.

Abstract:

Chalcones constitute an important class of natural products belonging to the flavonoids family that display several biological activities. In this context, chalcones received significant attention for their anti-tumor properties which are often associated to inhibition of polymerization of tubulins in the site of colchicine binding. Triazoles constitute an important class of heterocycles because of their varied biological activities and being regarded as an interesting unit with significant anticancer profile in many of the human cell lines. The recent discovery that some 1,2,3-triazole chalcones possess high citotoxicities against some cancer cell lines 5,6 encouraged us to the access of structurally simple chalcones possessing the 1,2,3-triazole core as potential anticancer agents.

Chalcones constitute an important class of natural products belonging to the flavonoids family that display several biological activities. In this context, chalcones received significant attention for their anti-tumor properties which are often associated to inhibition of polymerization of tubulins in the site of colchicine binding. Triazoles constitute an important class of heterocycles because of their varied biological activities and being regarded as an interesting unit with significant anticancer profile in many of the human cell lines. The recent discovery that some 1,2,3-triazole chalcones possess high citotoxicities against some cancer cell lines 5,6 encouraged us to the access of structurally simple chalcones possessing the 1,2,3-triazole core as potential anticancer agents.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391311340

Referências bibliográficas

• [1] 1Dyrager, C.; Wickström, M.; Fridén-Saxin, M.; Friberg, A.; Dahlén, K.; Wallén, E. A. A.; Gullbo, J.; Grøtli, M.; Luthman, K. Bioorg. Med. Chem. 2011, 19, 2659.
• [2] 2Kamal, A.; Shankaraiah, N.; Devaiah, V.; Laxma Reddy, K.; Juvekar, A.; Sen, S.; Kurianb, N.; Zingdeb, S. Bioorg. Med. Chem. Lett. 2008, 18, 1468.
• [3] 3 Wang, M.; Xia, Y.; Fan, Y.; Rocchi, P.; Qu, F.; Iovanna, J. L.; Peng, L. Bioorg. Med. Chem. Lett. 2010, 20, 5979.
• [4] 4 He, R.; Chen, Y.; Chen, Y.; Ougolkov, A. V.; Zhang, J. S.; Savoy, D. N.; Billadeau, D. D.; Kozikowski, A. P. J. Med. Chem. 2010, 53, 1347.
• [5] 5 Singh, P.; Raj, R.; Kumar, V.; Mahajan, M. P.; Bedi, P. M. S.; Kaur, T.; Saxena, A., K., Eur. J. Med. Chem. 2012, 47, 594 and references cited.
• [6] 6 Kamal, A.; Prabhakar, S.; Ramaiah, M. J.; Reddy, P. V.; Reddy, Ch. R.; Mallareddy, A.; Shankaraiah, N.; Reddy, T. L. N.; Pushpavalli, S. N. C. V. L.; Pal-Bhadra, M. Eur. J. Med. Chem. 2011, 46, 3820.
• [7] 7 Bakó,T.; Bakó. P.; Keglevich, G.; Báthori, N.; Czugler, M.; Tatai, J.; Novák, T.; Parlagh, G.; Töke, L., Tetrahedron: Asymmetry. 2003, 14, 1917.
• [8] 8 Silva Júnior, R. C.; Ferreira, V. F.; Pinheiro, F. Tetrahedron: Asymmetry 2004, 15, 3719.
• [9] 9 Fang, L.; Zheng-Feng, X.; Fang-Ming, L. Chem. J. Chinese Universities. 2006, 27, 1058.
• [10] 10Hui, Y. H.; Chen, C. M.; Xie, Z. F. Chinese Chem. Lett. 2012, 23, 525.

Como citar:

Pessôa, Jaqueline C.; Oliveira, Pãmella C. O. de; Fonseca, Meliza J. da C.; Pinheiro, Sergio; Muri, Estela M. F.; Dias, Ayres G.; Costa4, Paulo R. R.; "Synthesis of some 1,2,3-triazole-chalcones as potential anticancer agents", p-71-71. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391311340