Synthesis of quinolines derivatives by multicomponent reaction promoted by NbCl5

Synthesis of quinolines derivatives by multicomponent reaction promoted by NbCl5

Santos, Giovanny Carvalho dos; Bartolomeu, Aloisio de Andrade; Silva-Filho., Luiz Carlos da

Abstract:

The quinolines derivatives can be synthetized by Multicomponent Reaction (MCR) using niobium pentachloride that act as Lewis Acid provides an easy access to the preparation. The MCRs are defined as a process in which three or more reagents are combined in the same reaction “pot”, generating the products with good structural complexity with a single step, in addition to economy of atoms and selectivity that is an important feature in modern synthetic methodology. Quinolines and their derivatives are important not only as key structural units in many natural products but also as an important starting material for the chemical and pharmaceutical industry, for example it act as anti-inflammatory, anticancer, antituberculosis, etc. In this work we report a method to synthetize quinolines derivatives in the MCR using p-nitroaniline (1), benzaldehyde derivatives (2a-i), phenylacetylene (3), and niobium pentachloride as reaction promoter.

The quinolines derivatives can be synthetized by Multicomponent Reaction (MCR) using niobium pentachloride that act as Lewis Acid provides an easy access to the preparation. The MCRs are defined as a process in which three or more reagents are combined in the same reaction “pot”, generating the products with good structural complexity with a single step, in addition to economy of atoms and selectivity that is an important feature in modern synthetic methodology. Quinolines and their derivatives are important not only as key structural units in many natural products but also as an important starting material for the chemical and pharmaceutical industry, for example it act as anti-inflammatory, anticancer, antituberculosis, etc. In this work we report a method to synthetize quinolines derivatives in the MCR using p-nitroaniline (1), benzaldehyde derivatives (2a-i), phenylacetylene (3), and niobium pentachloride as reaction promoter.

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DOI: 10.5151/chempro-15bmos-BMOS2013_201392419018

Referências bibliográficas

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Como citar:

Santos, Giovanny Carvalho dos; Bartolomeu, Aloisio de Andrade; Silva-Filho., Luiz Carlos da; "Synthesis of quinolines derivatives by multicomponent reaction promoted by NbCl5", p-110-110. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201392419018