Synthesis of new naphthotriazoles derived from juglone as anticancer agents

Synthesis of new naphthotriazoles derived from juglone as anticancer agents

Silva, Wanderson A. da; Moreira, Vinicius N.; Campos, Vinícius R.; Ferreira, Vitor F.; Rocha, David R. da; Resende, Jackson A. L. C.; Montenegro, Raquel C.; Souza, Maria Cecília B. V. de; Cunha, and Anna C.

Abstract:

Juglone (3) is a natural compound isolated from nogueira plants (Juglans nigra) which has shown important cytotoxic activity.Quinones fused to N-heterocyclic aromatic rings have been reported in the literature as potential anticancer agents. On the basis of our experience in the field of the synthesis and biological evaluation of new quinone-carbohydrate conjugates and 1,2,3-triazole derivatives, we described the synthesis and in vitro anticancer activity studies of new compounds type 1 in which Juglone and 1,2,3-triazole frameworks are directly attached (Scheme).

Juglone (3) is a natural compound isolated from nogueira plants (Juglans nigra) which has shown important cytotoxic activity.Quinones fused to N-heterocyclic aromatic rings have been reported in the literature as potential anticancer agents. On the basis of our experience in the field of the synthesis and biological evaluation of new quinone-carbohydrate conjugates and 1,2,3-triazole derivatives, we described the synthesis and in vitro anticancer activity studies of new compounds type 1 in which Juglone and 1,2,3-triazole frameworks are directly attached (Scheme).

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DOI: 10.5151/chempro-15bmos-BMOS2013_201392591247

Referências bibliográficas

• [1] 1Silva, M. N.; Ferreira, V. F.; Souza, M. C. B. V., Quím. Nova 2003, 26, 407.
• [2] 2Oliveira,R.B.A., José, R., Quím. Nova 2002, 25, 976.
• [3] 3 Ferreira, V. F.; Jorqueira, A.; Souza, A. M. T; Silva, M. N.; Souza, M. C. B. V.; Gouve, R. M.; Rodrigues, C. R.; Pinto, A. V.; Castro, H. C.; Santos, D. O.; Araújo, H. P.; Bourguignon, S. C., Bioorg. Med. Chem. 2006, 14, 5459.

Como citar:

Silva, Wanderson A. da; Moreira, Vinicius N.; Campos, Vinícius R.; Ferreira, Vitor F.; Rocha, David R. da; Resende, Jackson A. L. C.; Montenegro, Raquel C.; Souza, Maria Cecília B. V. de; Cunha, and Anna C.; "Synthesis of new naphthotriazoles derived from juglone as anticancer agents", p-111-111. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201392591247