Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of new biologically actived azaspiro compounds

Martins, Lucimara J. ; Altei, Wanessa F. ; Schwalm, Cristiane S. ; Andricopulo, Adriano D. ; Coelho, Fernando ;

Abstract:

Recently we have developed a methodology for the synthesis of spirocyclohexadienones. These compounds showed moderate antibacterial activity, but good antiproliferative activities. The initial studies on the applications of PBN (- phenyl-tert-butylnitrone) and its derivatives for trapping free radicals in chemical systems1 associated with the antiproliferative activity exhibited by spirocyclohexadienones, such as Gimnastatin IK and Griseofulvin compounds, stimulated us to evaluate the synthesis and biological profile of some azaspiro derivatives. In this communication we disclosed the synthesis and the biological screening of new azaspiro compounds from Morita-Baylis- Hillman adducts.

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Palavras-chave: Morita-Baylis-Hillman, azaspiro, antiproliferative profile,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013917144424

Referências bibliográficas
  • [1] 1 Ferreira. B. R. V.; Pirovani, R. V.; Souza-Filho, L. G.; Coelho, F. Tetrahedron, 2009, 65, 7712.
  • [2] 2 Pirovani, R. V.; Ferreira, B. R. V.; Coelho, F. Synlett, 2009, 2333.
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  • [4] Basavaiah, D.; Badsara, S. S.; Veeraraghavaiah, G. Tetrahedron, 2013, 69, 7995.
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  • [6] 6 Rønnest, M. H. et al. J. Med. Chem. 2009, 52, 3342.
Como citar:

Martins, Lucimara J.; Altei, Wanessa F.; Schwalm, Cristiane S.; Andricopulo, Adriano D.; Coelho, Fernando; "Synthesis of new biologically actived azaspiro compounds", p. 285 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013917144424

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