Synthesis of new biologically actived azaspiro compounds

Synthesis of new biologically actived azaspiro compounds

Martins, Lucimara J.; Altei, Wanessa F.; Schwalm, Cristiane S.; Andricopulo, Adriano D.; Coelho, Fernando

Abstract:

Recently we have developed a methodology for the synthesis of spirocyclohexadienones. These compounds showed moderate antibacterial activity, but good antiproliferative activities. The initial studies on the applications of PBN (- phenyl-tert-butylnitrone) and its derivatives for trapping free radicals in chemical systems1 associated with the antiproliferative activity exhibited by spirocyclohexadienones, such as Gimnastatin IK and Griseofulvin compounds, stimulated us to evaluate the synthesis and biological profile of some azaspiro derivatives. In this communication we disclosed the synthesis and the biological screening of new azaspiro compounds from Morita-Baylis- Hillman adducts.

Recently we have developed a methodology for the synthesis of spirocyclohexadienones. These compounds showed moderate antibacterial activity, but good antiproliferative activities. The initial studies on the applications of PBN (- phenyl-tert-butylnitrone) and its derivatives for trapping free radicals in chemical systems1 associated with the antiproliferative activity exhibited by spirocyclohexadienones, such as Gimnastatin IK and Griseofulvin compounds, stimulated us to evaluate the synthesis and biological profile of some azaspiro derivatives. In this communication we disclosed the synthesis and the biological screening of new azaspiro compounds from Morita-Baylis- Hillman adducts.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013917144424

Referências bibliográficas

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Como citar:

Martins, Lucimara J.; Altei, Wanessa F.; Schwalm, Cristiane S.; Andricopulo, Adriano D.; Coelho, Fernando; "Synthesis of new biologically actived azaspiro compounds", p-285-285. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013917144424