Synthesis of lactones and lactams analogues to rubrolides as inhibitors of Enterococcus faecalis biofilm formation

Synthesis of lactones and lactams analogues to rubrolides as inhibitors of Enterococcus faecalis biofilm formation

Pereira, Ulisses A.; Barbosa, Luiz C. A.; Maltha, Célia R. A.; Demuner, Antônio Jacinto; Pimenta, Andréa de L.

Abstract:

Biofilms are a bacterial communities enclosed within an extracellular matrix capable to survive to antibiotics treatments. It has been estimated that 65-80% of the microbial infections occurring in the human body are biofilm-related. Therefore, identifying substances that are able to inhibit biofilm formation constitutes a promising approach for the development of new drugs. In this work, analogues to rubrolides, a class of natural γ-alkylidene-γ-lactones, and their corresponding lactams were synthesized and evaluated against E. faecalis biofilm formation.

Biofilms are a bacterial communities enclosed within an extracellular matrix capable to survive to antibiotics treatments. It has been estimated that 65-80% of the microbial infections occurring in the human body are biofilm-related. Therefore, identifying substances that are able to inhibit biofilm formation constitutes a promising approach for the development of new drugs. In this work, analogues to rubrolides, a class of natural γ-alkylidene-γ-lactones, and their corresponding lactams were synthesized and evaluated against E. faecalis biofilm formation.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013814154045

Referências bibliográficas

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• [2] 2 Davies, D. Nat. Rev. Drug Discov., 2010, 2, 114.
• [3] 3 Miao, S.; Andersen, R. J. J. Org. Chem., 56, 1991, 6275.

Como citar:

Pereira, Ulisses A.; Barbosa, Luiz C. A.; Maltha, Célia R. A.; Demuner, Antônio Jacinto; Pimenta, Andréa de L.; "Synthesis of lactones and lactams analogues to rubrolides as inhibitors of Enterococcus faecalis biofilm formation", p-154-154. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013814154045