Synthesis of C7−C31 fragment of (−)-cryptocaryol A

Synthesis of C7−C31 fragment of (−)-cryptocaryol A

Kuroishi, Paula K.; Jr., Emílio C. de Lucca; Dias, and Luiz C.

Abstract:

The natural product (+)-cryptocaryol A is an α-pyrone containing a 1,3-polyol moiety that was isolated in 2011 from the trees of Cryptocarya sp. (Figure 1). This compound is able to stabilize Pdcd4 (programmed cell death 4), a tumor suppressor protein that inhibits transformation, migration, and invasion of cancer cells in vitro. This work aims the synthesis of C7−C31 fragment of (−)-cryptocaryol A.

The natural product (+)-cryptocaryol A is an α-pyrone containing a 1,3-polyol moiety that was isolated in 2011 from the trees of Cryptocarya sp. (Figure 1). This compound is able to stabilize Pdcd4 (programmed cell death 4), a tumor suppressor protein that inhibits transformation, migration, and invasion of cancer cells in vitro. This work aims the synthesis of C7−C31 fragment of (−)-cryptocaryol A.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201381813140

Referências bibliográficas

• [1] 1 Grkovic, T.; Blees, J. S.; Colburn, N. H.; Schmid, T.; Thomas, C. L.; Henrich, C. J.; McMahon, J. B.; Gustafson, K. R. J. Nat. Prod. 2011, 74, 1015.
• [2] 2 Wang, Y.; O’Doherty, G. A. J. Am. Chem. Soc. 2013, 135, 9334.
• [3] 3 Schmid, T.; Jansen, A. P.; Baker, A. R.; Hegamyer, G.; Hagan, J. P.; Colburn, N. H. Cancer Res. 2008, 68, 1254.
• [4] 4 Dias, L. C.; Polo, E. C.; de Lucca Jr., E. C.; Ferreira, M. A. B. In Modern Methods in Stereoselective Aldol Reactions, vol. 1; Mahrwald, R., ed.; Wiley-VCH Verlag: Weinheim, Germany, 2013.

Como citar:

Kuroishi, Paula K.; Jr., Emílio C. de Lucca; Dias, and Luiz C.; "Synthesis of C7−C31 fragment of (−)-cryptocaryol A", p-41-41. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201381813140