Synthesis of 2,5-disubstituted selenazoles by O-Se exchange

Synthesis of 2,5-disubstituted selenazoles by O-Se exchange

Pizzo, Chiara; Mahler, Graciela

Abstract:

The interest in organoselenium compounds has been growing during the last decades due to its importance in synthetic chemistry. In particular, selenazole heterocycles are being studied because of its interesting biological properties. As part of our studies involving organoselenium compounds, we explored the cycloisomerization of alkynyl selenoamides. Herein, we report a novel tandem procedure for the synthesis of 2,5- disubtituted selenazoles by cycloisomerization of propargyl selenoamides.

The interest in organoselenium compounds has been growing during the last decades due to its importance in synthetic chemistry. In particular, selenazole heterocycles are being studied because of its interesting biological properties. As part of our studies involving organoselenium compounds, we explored the cycloisomerization of alkynyl selenoamides. Herein, we report a novel tandem procedure for the synthesis of 2,5- disubtituted selenazoles by cycloisomerization of propargyl selenoamides.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013819141440

Referências bibliográficas

• [1] 1 Koketsu, M.; Ishihara, H. Current Org. Chem. 2003, 7, 175.
• [2] 2 Pizzo, C.; Faral-Tello, P.; Salinas, G.; Flo, M.; Robello, C.; Wipf, P.;
• [3] Mahler, SG. Med. Chem. Commun. 2012, 3, 362-367

Como citar:

Pizzo, Chiara; Mahler, Graciela; "Synthesis of 2,5-disubstituted selenazoles by O-Se exchange", p-172-172. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013819141440