Synthesis of 1-H-1,2,3-triazole-1,4-naphthoquinones as potential antifungal agents

Synthesis of 1-H-1,2,3-triazole-1,4-naphthoquinones as potential antifungal agents

Melo, Valentina N. e; Valença, Wagner O.; Nascimento, Wilson S. do; Cordeiro, Rossana A.; Marques, Francisca J. F.; Sidrim, José Júlio C.; Camara, Celso A.; Oliveira, Ronaldo N. de

Abstract:

1,4-Naphthoquinone derivatives were found to possess remarkable biological activities, such as antimicrobial and anticancer. Chemical structures containing 1,4-naphthoquinone conjugated with 1,2,3-triazole are important building blocks for our research due to rapid preparation, as well as reported by us biological activities against T. cruzi and Leishmania parasites. In this work, we had interest in perform the synthesis of 1,2,3-triazole- 1,4-naphthoquinones using conventional protocols, and then study their antifungal activity.

1,4-Naphthoquinone derivatives were found to possess remarkable biological activities, such as antimicrobial and anticancer. Chemical structures containing 1,4-naphthoquinone conjugated with 1,2,3-triazole are important building blocks for our research due to rapid preparation, as well as reported by us biological activities against T. cruzi and Leishmania parasites. In this work, we had interest in perform the synthesis of 1,2,3-triazole- 1,4-naphthoquinones using conventional protocols, and then study their antifungal activity.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013929205147

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Como citar:

Melo, Valentina N. e; Valença, Wagner O.; Nascimento, Wilson S. do; Cordeiro, Rossana A.; Marques, Francisca J. F.; Sidrim, José Júlio C.; Camara, Celso A.; Oliveira, Ronaldo N. de; "Synthesis of 1-H-1,2,3-triazole-1,4-naphthoquinones as potential antifungal agents", p-293-293. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013929205147