Synthesis and Evaluation against Mycobacterium tuberculosis of Phenazine-triazole-linked from ortho-Naphthoquinones

Synthesis and Evaluation against Mycobacterium tuberculosis of Phenazine-triazole-linked from ortho-Naphthoquinones

Jardim, Guilherme A. M.; Dias, Gleiston G.; Diogo, Emilay B. T.; Silva, Diego A. C.; Rodrigues, Bernardo L.; Cantos, Jéssica; Silva, Pedro E. A.; Júnior, Eufrânio N. da Silva

Abstract:

Phenazine compounds have been reported as new active substances againt Mycobaterium Tuberculosis strains. In the last years, click chemistry reaction was used to incorporate a 1,2,3-triazole ring in bioactive heterocyclic compounds, as for instance, bioactive phenazines. This strategy, known as molecular hybridization is important in medicinal chemistry for potentiate the pharmacological activities and reduce the sides effects. In this context, we described herein the synthesis and evaluation against Mycobacterium tuberculosis of new phenazine-triazole-linked.

Phenazine compounds have been reported as new active substances againt Mycobaterium Tuberculosis strains. In the last years, click chemistry reaction was used to incorporate a 1,2,3-triazole ring in bioactive heterocyclic compounds, as for instance, bioactive phenazines. This strategy, known as molecular hybridization is important in medicinal chemistry for potentiate the pharmacological activities and reduce the sides effects. In this context, we described herein the synthesis and evaluation against Mycobacterium tuberculosis of new phenazine-triazole-linked.

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DOI: 10.5151/chempro-15bmos-BMOS2013_20139916214

Referências bibliográficas

• [1] 1. Salas, C. O et. al.. Curr. Med. Chem. 18, 2011, 144 – 161.
• [2] 2. da Silva Júnior, E. N. et. al. Euro. Jour. Med. Chem. 46, 2011, 4521 - 4529.
• [3] 3. Gmeiner, P. J. et. al. Med. Chem. 2009, 52, 6860.

Como citar:

Jardim, Guilherme A. M.; Dias, Gleiston G.; Diogo, Emilay B. T.; Silva, Diego A. C.; Rodrigues, Bernardo L.; Cantos, Jéssica; Silva, Pedro E. A.; Júnior, Eufrânio N. da Silva; "Synthesis and Evaluation against Mycobacterium tuberculosis of Phenazine-triazole-linked from ortho-Naphthoquinones", p-25-25. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_20139916214