Synthesis and antitumor activity of novel Schiff bases derived from 6-hydroxy-1,3-benzoxathiol-2-one

Synthesis and antitumor activity of novel Schiff bases derived from 6-hydroxy-1,3-benzoxathiol-2-one

Chazin, Eliza de L.; Sanches, Paola de S.; Júnior, Walcimar T. Vellasco; Gomes, Claudia R. B.; Montenegro, Raquel C.; Vasconcelos, Thatyana R. A.

Abstract:

Heterocycles comprise a class of compounds that draw synthetic interest due to their occurrence on natural products and pharmacologically active substances. Among them, 1,3-benzoxathiol-2-ones and its derivatives are important pharmacophores that exhibit antibacterial, antimycotic, antioxidant, antitumor, and anti-inflammatory activities. Schiff bases have also been found to possess interesting and diversified biological properties such as antibacterial, antitumor and antioxidant. In this context, we have proposed to synthesize novel Schiff bases 4 containing the 1,3- benzoxathiol-2-one moiety with potential antitumor activity (Figure 1).

Heterocycles comprise a class of compounds that draw synthetic interest due to their occurrence on natural products and pharmacologically active substances. Among them, 1,3-benzoxathiol-2-ones and its derivatives are important pharmacophores that exhibit antibacterial, antimycotic, antioxidant, antitumor, and anti-inflammatory activities. Schiff bases have also been found to possess interesting and diversified biological properties such as antibacterial, antitumor and antioxidant. In this context, we have proposed to synthesize novel Schiff bases 4 containing the 1,3- benzoxathiol-2-one moiety with potential antitumor activity (Figure 1).

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013913114235

Referências bibliográficas

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• [3] Org. Chem. 2011, 8, 103-109.
• [4] 3 Anand, P.; Patil, V.M.; Sharma, V.K.; Khosa, R.L.; Masand, N. Int J.
• [5] Drug. Des. Discov. 2012, 3, 851-868.

Como citar:

Chazin, Eliza de L.; Sanches, Paola de S.; Júnior, Walcimar T. Vellasco; Gomes, Claudia R. B.; Montenegro, Raquel C.; Vasconcelos, Thatyana R. A.; "Synthesis and antitumor activity of novel Schiff bases derived from 6-hydroxy-1,3-benzoxathiol-2-one", p-223-223. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013913114235