Syntheses of β-hydroxy-α-amino esters and non-proteinogenic α-amino acids from Morita-Baylis-Hillman adducts.

Syntheses of β-hydroxy-α-amino esters and non-proteinogenic α-amino acids from Morita-Baylis-Hillman adducts.

Ullah, Hamid; Ferreira, Andre V.; Jr, Manoel T. Rodrigues; Coelho, Fernando

Abstract:

β-hydroxy-α-amino esters are found in various bioactive natural. On the other hand non proteinogenic amino acids play a vital role in the syntheses of various bioactive compounds and drugs. For example “DOPA” is employed against Parkinson’s disease. Thus, both of their biological and synthetic role make them attractive for synthetic and medicinal community. Thus the goal of our work is a diastereoselective syntheses of the β-hydroxy- α-amino esters, non-proteinogenic amino acids including racemic “DOPA” from MBH adducts.

β-hydroxy-α-amino esters are found in various bioactive natural. On the other hand non proteinogenic amino acids play a vital role in the syntheses of various bioactive compounds and drugs. For example “DOPA” is employed against Parkinson’s disease. Thus, both of their biological and synthetic role make them attractive for synthetic and medicinal community. Thus the goal of our work is a diastereoselective syntheses of the β-hydroxy- α-amino esters, non-proteinogenic amino acids including racemic “DOPA” from MBH adducts.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013819143637

Referências bibliográficas

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Como citar:

Ullah, Hamid; Ferreira, Andre V.; Jr, Manoel T. Rodrigues; Coelho, Fernando; "Syntheses of β-hydroxy-α-amino esters and non-proteinogenic α-amino acids from Morita-Baylis-Hillman adducts.", p-173-173. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013819143637