Studies toward total synthesis of tautomycetin

Studies toward total synthesis of tautomycetin

Sant’Ana, Danilo P.; Fiqueiredo, Renata Marcia de; Campagne, Jean-Marc; Dias., Luiz Carlos

Abstract:

Tautomycetin is a polyketide natural product recognized as an inhibitor of serine/threonine phosphatases type I. In spite of this important activity, there is no total synthesis described in the literature. For this reason, we have proposed a project aiming to the total synthesis of tautomycetin. We wish to describe here our approach to fragments C7’-17 and C1-C12 of tautomycetin.

Tautomycetin is a polyketide natural product recognized as an inhibitor of serine/threonine phosphatases type I. In spite of this important activity, there is no total synthesis described in the literature. For this reason, we have proposed a project aiming to the total synthesis of tautomycetin. We wish to describe here our approach to fragments C7’-17 and C1-C12 of tautomycetin.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013818172811

Referências bibliográficas

• [1] 1 Sakoff, J. A. ; McCluskey, A. Curr. Pharm. Des. 2004, 10, 1139.
• [2] 2 Oikawa, H. Curr. Med. Chem. 2002, 9, 2033.
• [3] 3 Negishi, E. ARKIVOC 2011, 34.

Como citar:

Sant’Ana, Danilo P.; Fiqueiredo, Renata Marcia de; Campagne, Jean-Marc; Dias., Luiz Carlos; "Studies toward total synthesis of tautomycetin", p-163-163. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013818172811