Semi-synthesis of Purpurinimides: The search for more effective PDT agents

Semi-synthesis of Purpurinimides: The search for more effective PDT agents

Uliana, Marciana P.; Brocksom, Timothy J.; Oliveira, Kleber T. de; Bagnato, Vanderlei S.; Kurachi., Cristina

Abstract:

Photodynamic therapy (PDT) is an emergent technique for treatment of diseases caused by resistant microorganisms, skin cancer and other diseases. Although the use of various photosensitizers (PS) in PDT has been reported, there are still many challenges to be overcome. Strategies for the synthesis of new photosensitizers, based on chlorophyll moieties, are being developed in our research group. The aim is to synthesize new molecules with absorption in the near IR that will be more adequate for PDT treatments.

Photodynamic therapy (PDT) is an emergent technique for treatment of diseases caused by resistant microorganisms, skin cancer and other diseases. Although the use of various photosensitizers (PS) in PDT has been reported, there are still many challenges to be overcome. Strategies for the synthesis of new photosensitizers, based on chlorophyll moieties, are being developed in our research group. The aim is to synthesize new molecules with absorption in the near IR that will be more adequate for PDT treatments.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013912124716

Referências bibliográficas

• [1] 1 Ferraz, R, C, M, C.; Fontana, C. R.; Ribeiro, A. P.; Trindade, F. Z.;
• [2] Bartoloni, F. H.; Baader, J. W.; Lins, E. C.; Bagnato, V. S.; Kurachi, C. J.
• [3] Photochem Photobiol B, 2011, 103, 87–92.
• [4] 2
• [5] Garland, M, J.; Cassidy , C. M. Woolf son, D.; Donnely , R. F.; Future Med.
• [6] Chem. 2009, 1, 667-691.

Como citar:

Uliana, Marciana P.; Brocksom, Timothy J.; Oliveira, Kleber T. de; Bagnato, Vanderlei S.; Kurachi., Cristina; "Semi-synthesis of Purpurinimides: The search for more effective PDT agents", p-210-210. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013912124716