Selective semi-synthesis of dihydrocucurbitacin B glycosides

Selective semi-synthesis of dihydrocucurbitacin B glycosides

MOROTTI, A. L. M.; ZIMMERMANN, L. A.; MACHADO, V. R.; SCHENKEL, E. P.; BERNARDES, L. S. C.

Abstract:

Cucurbitacin glycosides are natural compounds which have gained attention due to their biological activities, mainly against different cancer cells. Our research group has been investigating the preparation of cucurbitacin glycosides by semisynthesis, considering the difficulty of obtaining them from natural sources.

Cucurbitacin glycosides are natural compounds which have gained attention due to their biological activities, mainly against different cancer cells. Our research group has been investigating the preparation of cucurbitacin glycosides by semisynthesis, considering the difficulty of obtaining them from natural sources.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013101412589

Referências bibliográficas

• [1] 1 Chen, J. C.; Chiu, M. H.; Nie, R. L.; Cordel, G. A.; Qiu, S. X. Natural Product Report. 2005, 22, 3, 386-399.
• [2] 2 Lang, K. L.; Silva, I. T.; Zimmermann, L. A.; Machado, V. R.; Teixeira, M. R.; Lapuh, M. I.; Galetti, M. A.; Palermo, J. A.; Cabrera, G. M.; Bernardes, L. S. C.; Simões, C. M. O.; Schenkel, E. P.; Caro, M. S. B.; Durán, F. J. Bioorganic And Medicinal Chemistry. 2012, 20, 3016-3030.
• [3] 3 Kartha, K. P. R.; Field, R. A. Tetrahedron. 1997, 53, 34, 11753-11766.
• [4] 4Ren, T.; Zhang, G.; Liu, D. Tetrahedron Letters. 2001, 42, 6, 1007-1010
• [5] 5 Cheng, H.; Cao, X.; Xian, M.; Fang, L.; Cai, T. B.; Ji, J. J.; Tunac, J. B.; Sun, D.; Wang, P. G. Journal of Medicinal chemistry. 2005, 48, 2, 645-652.

Como citar:

MOROTTI, A. L. M.; ZIMMERMANN, L. A.; MACHADO, V. R.; SCHENKEL, E. P.; BERNARDES, L. S. C.; "Selective semi-synthesis of dihydrocucurbitacin B glycosides", p-129-129. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013101412589