Preparation and preliminiar evaluation of new organometallic bases from cis-2,6-dimethylpiperidine

Preparation and preliminiar evaluation of new organometallic bases from cis-2,6-dimethylpiperidine

Pereira, Natália de Araujo; Soldi, Rafael Augusto; Clososki, Giuliano Cesar; Pina, Evelyn Mirella Lopes

Abstract:

Recently, magnesiate and zincate reagents have proven their synthetic importance for the functionalization of arenes. In addition, mixed Li/Mg and Li/Zn amides prepared from 2,2,6,6- tetramethylpyperidine (TMPH) are highly soluble and active bases that allow smoothly metalatation of various aromatic and heteroarenes with an excellent fuctional group tolerance. In this work, we have been investigating the preparation and the reactivity of mixed metal bases from cis-2,6-dimethylpiperidine (DMPH) as alternative for TMP-metal bases.

Recently, magnesiate and zincate reagents have proven their synthetic importance for the functionalization of arenes. In addition, mixed Li/Mg and Li/Zn amides prepared from 2,2,6,6- tetramethylpyperidine (TMPH) are highly soluble and active bases that allow smoothly metalatation of various aromatic and heteroarenes with an excellent fuctional group tolerance. In this work, we have been investigating the preparation and the reactivity of mixed metal bases from cis-2,6-dimethylpiperidine (DMPH) as alternative for TMP-metal bases.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915232924

Referências bibliográficas

• [1] 1Kondo, Y.; Shilai, H.; Uchiyama, M.; Sakamoto, T. J. Am.
• [2] Chem. Soc. 1999, 121, 3539.
• [3] 2 Bresser, T.; Mosrin, M.; Monzon, G.; Knochel, P. J. Org. Chem.
• [4] 2010, 75, 4686.

Como citar:

Pereira, Natália de Araujo; Soldi, Rafael Augusto; Clososki, Giuliano Cesar; Evelyn Mirella Lopes Pina Diniz; "Preparation and preliminiar evaluation of new organometallic bases from cis-2,6-dimethylpiperidine", p-280-280. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915232924