Preliminary studies on Cu/SiO2 catalyzed imidazo[1,2-a]pyridine multicomponent synthesis

Preliminary studies on Cu/SiO2 catalyzed imidazo[1,2-a]pyridine multicomponent synthesis

Salles*, Helena D. de; Silva, Tiago L. da; Radatz, Cátia S.; Schneider, Paulo H.

Abstract:

Imidazo[1,2-a]pyridines are important building blocks for development of new molecules with important biological applications. As already reported, this type of compound presents anxiolytic and sedative activities, and are commercially available as Zolpidem for example. Due to this characteristics the study and development of new environment friendly methodologies are important. In this context we propose the use of composite Cu/SiO2 as an heterogeneous catalyst in the multicomponent reaction for the synthesis of this type of heterocycles.

Imidazo[1,2-a]pyridines are important building blocks for development of new molecules with important biological applications. As already reported, this type of compound presents anxiolytic and sedative activities, and are commercially available as Zolpidem for example. Due to this characteristics the study and development of new environment friendly methodologies are important. In this context we propose the use of composite Cu/SiO2 as an heterogeneous catalyst in the multicomponent reaction for the synthesis of this type of heterocycles.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391521851

Referências bibliográficas

• [1] 1 Guieffier, C.-E.; Gueiffier, A. Mini-Reviews in Medicinal Chemistry, 2007, 7, 888.
• [2] 2 Chernyak, N.; Gevorgyan, V. Angew. Chem. Int. Ed. 2010, 49, 2743.
• [3] 3 Russowsky, D.; Benvenutti, E. V.; Roxo, G. S.; Grasel, F. Lett. Org. Chem. 2007, 4, 39

Como citar:

Salles*, Helena D. de; Silva, Tiago L. da; Radatz, Cátia S.; Schneider, Paulo H.; "Preliminary studies on Cu/SiO2 catalyzed imidazo[1,2-a]pyridine multicomponent synthesis", p-100-100. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391521851