PHARMACEUTICAL AEROSOLS DEPOSITION DURING INHALATION, BREATH HOLDING AND EXHALATION USING CFD

PHARMACEUTICAL AEROSOLS DEPOSITION DURING INHALATION, BREATH HOLDING AND EXHALATION USING CFD

AUGUSTO, L. L. X.; LOPES, G. C.; GONÇALVES, J. A. S.

Artigo:

In the last decades, the air pollution lead to an increase in the impact of the particle deposition in human lungs, especially with respect to respiratory diseases. Since the airway bifurcations are difficult regions to investigate, the Computational Fluid Dynamics (CFD) can be an alternative to the study of pharmaceutical aerosols that are used to the treatment of some respiratory diseases. In this study, the particle deposition was analyzed in a three-dimensional model of four ramifications or three bifurcations during three different situations: inhalation, exhalation and breath holding. The aim was to verify the medical recommendations to hold the breath during few seconds after inhale the pharmaceutical aerosols by comparison of the deposition of particles with 5 µm diameter. The numerical results of deposition during inhalation was compared to experimental data from the literature and showed good agreements. The results showed that the number of collected aerosols in the airway walls was greater for the situation of breath holding, which, in fact, confirms the medical recommendations. During the exhalation, the particles leave the domain, which would not be an interesting action after inhale the medicines.

In the last decades, the air pollution lead to an increase in the impact of the particle deposition in human lungs, especially with respect to respiratory diseases. Since the airway bifurcations are difficult regions to investigate, the Computational Fluid Dynamics (CFD) can be an alternative to the study of pharmaceutical aerosols that are used to the treatment of some respiratory diseases. In this study, the particle deposition was analyzed in a three-dimensional model of four ramifications or three bifurcations during three different situations: inhalation, exhalation and breath holding. The aim was to verify the medical recommendations to hold the breath during few seconds after inhale the pharmaceutical aerosols by comparison of the deposition of particles with 5 µm diameter. The numerical results of deposition during inhalation was compared to experimental data from the literature and showed good agreements. The results showed that the number of collected aerosols in the airway walls was greater for the situation of breath holding, which, in fact, confirms the medical recommendations. During the exhalation, the particles leave the domain, which would not be an interesting action after inhale the medicines.

Palavras-chave:

DOI: 10.5151/chemeng-cobeq2014-1489-19037-152591

Referências bibliográficas

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Como citar:

AUGUSTO, L. L. X.; LOPES, G. C.; GONÇALVES, J. A. S.; "PHARMACEUTICAL AEROSOLS DEPOSITION DURING INHALATION, BREATH HOLDING AND EXHALATION USING CFD", p-5985-5992. In: Anais do XX Congresso Brasileiro de Engenharia Química - COBEQ 2014 [= Blucher Chemical Engineering Proceedings, v.1, n.2]. São Paulo: Blucher, 2015.
ISSN 23591757, DOI 10.5151/chemeng-cobeq2014-1489-19037-152591