Peptide and cyclopetide synthesis via Ugi and click reactions under microwave irradiation and in continuous flow system

Peptide and cyclopetide synthesis via Ugi and click reactions under microwave irradiation and in continuous flow system

Salvador, Carlos Eduardo M.; Brito, José Giovanni L.; Miranda, Leandro Soter de M.; Souza, Rodrigo O. M. A.; Andrade, Carlos Kleber Z.

Abstract:

Cyclopeptides usually stand out due to their structural characteristics and their physico-chemical and biological properties of interest for use as therapeutic agents. The increasing use of microreactors as a promising technology for the synthesis of compounds with pharmaceutical application and the absence of reports in the literature investigating the Ugi / Click reactions in cyclopeptide synthesis in continuous flow systems were the major motivations for this work.

Cyclopeptides usually stand out due to their structural characteristics and their physico-chemical and biological properties of interest for use as therapeutic agents. The increasing use of microreactors as a promising technology for the synthesis of compounds with pharmaceutical application and the absence of reports in the literature investigating the Ugi / Click reactions in cyclopeptide synthesis in continuous flow systems were the major motivations for this work.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915235633

Referências bibliográficas

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• [4] 3 - Glasnov, T. N.; Kappe, C. O. Chem. Eur. J. 2011, 17, 11956.

Como citar:

Salvador, Carlos Eduardo M.; Brito, José Giovanni L.; Miranda, Leandro Soter de M.; Souza, Rodrigo O. M. A.; Andrade, Carlos Kleber Z.; "Peptide and cyclopetide synthesis via Ugi and click reactions under microwave irradiation and in continuous flow system", p-281-281. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915235633