Organoselenium functionalized nitrogen heterocycles: a proposition for new antimalarials.

Organoselenium functionalized nitrogen heterocycles: a proposition for new antimalarials.

Silva, Gabriela D. da; Bagnaresi, Piero; Cunha, Rodrigo L. O. R.

Abstract:

Every year, approximately 250 millions of peoples are diagnosed with malaria. The synthesis of hybrid compounds aims to maximize the performance of drugs. Contemplating two distinct properties, the similarity with chloroquine and moiety containing selenium, as an inhibitor of proteases involved in the life cycle of the parasite. In this work, we realized synthesis of various hybrid compounds via nucleophilic aromatic substitution reactions between arilselenoaniline and diclhoroquinolines and chloropyridines.

Every year, approximately 250 millions of peoples are diagnosed with malaria. The synthesis of hybrid compounds aims to maximize the performance of drugs. Contemplating two distinct properties, the similarity with chloroquine and moiety containing selenium, as an inhibitor of proteases involved in the life cycle of the parasite. In this work, we realized synthesis of various hybrid compounds via nucleophilic aromatic substitution reactions between arilselenoaniline and diclhoroquinolines and chloropyridines.

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DOI: 10.5151/chempro-15bmos-BMOS2013_20131014142313

Referências bibliográficas

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Como citar:

Silva, Gabriela D. da; Bagnaresi, Piero; Cunha, Rodrigo L. O. R.; "Organoselenium functionalized nitrogen heterocycles: a proposition for new antimalarials.", p-303-303. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_20131014142313