Nickel-Catalyzed Borylation of Halides and Pseudohalides with Tetrahydroxydiboron [B2(OH)4]1

Nickel-Catalyzed Borylation of Halides and Pseudohalides with Tetrahydroxydiboron [B2(OH)4]1

Cavalcanti*, Livia N.; Molander, Gary A.

Abstract:

Arylboronic acids are important structures in organic synthesis and have also find application as biological and medicinal target. Traditional methods to synthesize these molecules utilizes wasteful boron sources, such as bis(pinacolato) diboron (B2Pin2). Recently, our group developed the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron [B2(OH)4] reagent. The limitations associated with the method along with the high cost of palladium prompted us to develop a nickel-catalyzed borylation of aryl and heteroaryl halides utilizing BBA.

Arylboronic acids are important structures in organic synthesis and have also find application as biological and medicinal target. Traditional methods to synthesize these molecules utilizes wasteful boron sources, such as bis(pinacolato) diboron (B2Pin2). Recently, our group developed the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron [B2(OH)4] reagent. The limitations associated with the method along with the high cost of palladium prompted us to develop a nickel-catalyzed borylation of aryl and heteroaryl halides utilizing BBA.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013914135357

Referências bibliográficas

• [1] 1 Molander, G. A.; Cavalcanti, L. N. J. Org. Chem. 2013, 78, 6427.
• [2] 2 Boronic Acids; Hall, D. G., Ed.; Wiley-VCH: Weinheim, 2011.

Como citar:

Cavalcanti*, Livia N.; Molander, Gary A.; "Nickel-Catalyzed Borylation of Halides and Pseudohalides with Tetrahydroxydiboron [B2(OH)4]1", p-240-240. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013914135357