Abstract:

Asymmetric organocatalysis is recognized as an efficient and versatile method for the stereoselective preparation of chiral compounds. Over 300 reactions have been developed using organocatalyzed processes. This strategy is attractive because in most cases the catalysts are nontoxic, readily available and stable. Another feature is that most reactions tolerate water and air. In the present work, we describe the synthesis of new thiazolidine-based organocatalysts and their application in asymmetric direct aldol additions.