Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

Idioma principal

New strategy for the synthesis of Bromacil and their analogous

Zanatta, Nilo ; Santos, Josiane M. dos ; Silveira, Alessandra da ; Bonacorso, Hélio G. ; Martins., Marcos A. P. ;

Abstract:

The introduction of halogenes and halogenated groups in organic molecules promotes significant changes in their chemical, physical and biological properties. Halogenation reactions at position 5 of uracils and pyrimidinones has been applied to obtain new substances with biological, industrial and commercial concern. As the examples we cited Bromacil (I)(Herbicide) and 5-Fluorouracil (II)(Antitumor) (Figure 1). Furthermore, 5- halouracilas can be used as synthetic intermediates in coupling reactions. In this work we present the synthesis of 5-bromo uracils (14-17), the Bromacil analogous, through a methodology quickly and efficiently.

Abstract:

Download (PDF)

Palavras-chave: bromination, 5-bromo uracil, analogous Bromacil,

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201371723718

Referências bibliográficas
  • [1] 1 Ondi, L.; Lefebvre, O.; Schlosser, M. Eur. J. Org. Chem. 2004, 17, 3714.
  • [2] 2 Barret, H. B.; Goodman, I.; Dittmer, K. J. Am. Chem. Soc. 1948, 70, 1753.
  • [3] 3 Skulnick, H. I.; Ldens, J. H.; Wendling, M. G.; Glenn, E. M.; Rohloff, N. A.; Smith, R. J.; Wierenga, W. J. Med. Chem. 1986, 29, 1499.
  • [4] 4Miyaschita, O.; Matsumura, K.; Shimadzu, H.; Hashimoto, N. Chem. Pharm. Bull. 1981, 29, 3181.
  • [5] 5 Kusturin, C.; Liebeskind, L. S.; Rahman, H.; Sample, K.; Schweitzer, B.; Srogl, J.; Neumann, W. L. Org. Lett. 2003, 5, 4349.
Como citar:

Zanatta, Nilo; Santos, Josiane M. dos; Silveira, Alessandra da; Bonacorso, Hélio G.; Martins., Marcos A. P.; "New strategy for the synthesis of Bromacil and their analogous", p. 37 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201371723718

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações