New strategy for the synthesis of Bromacil and their analogous

New strategy for the synthesis of Bromacil and their analogous

Zanatta, Nilo; Santos, Josiane M. dos; Silveira, Alessandra da; Bonacorso, Hélio G.; Martins., Marcos A. P.

Abstract:

The introduction of halogenes and halogenated groups in organic molecules promotes significant changes in their chemical, physical and biological properties. Halogenation reactions at position 5 of uracils and pyrimidinones has been applied to obtain new substances with biological, industrial and commercial concern. As the examples we cited Bromacil (I)(Herbicide) and 5-Fluorouracil (II)(Antitumor) (Figure 1). Furthermore, 5- halouracilas can be used as synthetic intermediates in coupling reactions. In this work we present the synthesis of 5-bromo uracils (14-17), the Bromacil analogous, through a methodology quickly and efficiently.

The introduction of halogenes and halogenated groups in organic molecules promotes significant changes in their chemical, physical and biological properties. Halogenation reactions at position 5 of uracils and pyrimidinones has been applied to obtain new substances with biological, industrial and commercial concern. As the examples we cited Bromacil (I)(Herbicide) and 5-Fluorouracil (II)(Antitumor) (Figure 1). Furthermore, 5- halouracilas can be used as synthetic intermediates in coupling reactions. In this work we present the synthesis of 5-bromo uracils (14-17), the Bromacil analogous, through a methodology quickly and efficiently.

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DOI: 10.5151/chempro-15bmos-BMOS2013_201371723718

Referências bibliográficas

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Como citar:

Zanatta, Nilo; Santos, Josiane M. dos; Silveira, Alessandra da; Bonacorso, Hélio G.; Martins., Marcos A. P.; "New strategy for the synthesis of Bromacil and their analogous", p-37-37. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201371723718