New modular structures constructed by click chemistry

New modular structures constructed by click chemistry

Valdomir, Guillermo; Padrón, José M.; Padrón, Juan I.; Martín, Víctor S.; Davyt, Danilo

Abstract:

Inspired by diferent natural compounds withcytotoxic activity, we synthesised new modularcompounds by Click Chemistry, using two kinds ofbuilding blocks which can be easily coupled. TheCu(I) catalyzed version of the Huisgen reaction, wasthe tool selected for the coupling of the buildingblocks. These compounds have been tested todetermine their antiproliferative activity against fivehuman solid tumor cell lines.

Inspired by diferent natural compounds withcytotoxic activity, we synthesised new modularcompounds by Click Chemistry, using two kinds ofbuilding blocks which can be easily coupled. TheCu(I) catalyzed version of the Huisgen reaction, wasthe tool selected for the coupling of the buildingblocks. These compounds have been tested todetermine their antiproliferative activity against fivehuman solid tumor cell lines.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201381919619

Referências bibliográficas

• [1] 1 Kolb, H. C.; Finn, M. G.; Sharpless, K. B. Angew. Chem. Int. Ed. 2001, 40, 2004.
• [2] 2 Fuchs, P. L.; Corey, E. J. Tetrahedron Lett. 1972, 13, 3769.
• [3] 3 Phillips, A. J.; Uto, Y.; Wipf, P.; Reno, M. J.; Williams, D. R. Org. Lett. 2000, 2, 1165.

Como citar:

Valdomir, Guillermo; Padrón, José M.; Padrón, Juan I.; Martín, Víctor S.; Davyt, Danilo; "New modular structures constructed by click chemistry", p-48-48. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201381919619