New approach of side chain N-acylation and C-oxidation reactions of CF3-containing 7-amino-8-methylquinolines

New approach of side chain N-acylation and C-oxidation reactions of CF3-containing 7-amino-8-methylquinolines

Andrighetto, Rosália; Bonacorso, Helio G.; Wiethan, Carson W.; Stefanello, Felipe S.; Martins, Marcos A. P.; Zanatta, Nilo

Abstract:

Compounds containing the –CO–N(R)–CO– function have shown a variety of important pharmacological properties, particularly acting as anticonvulsants. On the other hand, quinoline ring systems deserve special interest. We can also highlight that the class of five-membered heterocycles as oxazolidinones, pyrrolidin-2,5-diones and thiophenes derivatives attract considerable attention due to the broad range of pharmacological properties and their chemical applications. So, considering the great biological importance and employment of amino-heterocycles as starting material for the synthesis of new heterocycles, the purpose of this work is to report the results of an investigation of the chemical behavior of 7-amino-8-methylquinolines in side chain N-acylation and C-oxidation reactions.

Compounds containing the –CO–N(R)–CO– function have shown a variety of important pharmacological properties, particularly acting as anticonvulsants. On the other hand, quinoline ring systems deserve special interest. We can also highlight that the class of five-membered heterocycles as oxazolidinones, pyrrolidin-2,5-diones and thiophenes derivatives attract considerable attention due to the broad range of pharmacological properties and their chemical applications. So, considering the great biological importance and employment of amino-heterocycles as starting material for the synthesis of new heterocycles, the purpose of this work is to report the results of an investigation of the chemical behavior of 7-amino-8-methylquinolines in side chain N-acylation and C-oxidation reactions.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013927132252

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Como citar:

Andrighetto, Rosália; Bonacorso, Helio G.; Wiethan, Carson W.; Stefanello, Felipe S.; Martins, Marcos A. P.; Zanatta, Nilo; "New approach of side chain N-acylation and C-oxidation reactions of CF3-containing 7-amino-8-methylquinolines", p-291-291. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013927132252