New 1,3,4-Oxadiazolyl-pyrazolyl-Pyridine Tricyclic Scaffold Derivatives: Synthesis and Structure Assignment by NMR and DFT Calculations

New 1,3,4-Oxadiazolyl-pyrazolyl-Pyridine Tricyclic Scaffold Derivatives: Synthesis and Structure Assignment by NMR and DFT Calculations

Paim, Gisele R.; Meira, Susiane C.; Pittaluga, Everton P.; Porte, Liliane M. F.; Meyer, Alexandre R.; Navarini, Jussara; Bonacorso, Helio G.

Abstract:

Among five-membered aromatic heterocycles, 1,3,4- oxadiazoles are important class of aromatic heterocycles displaying a broad spectrum of biological activities, such as antimicrobial, anti-inflammatoy, analgesic, anticonvulsivant, anti-hypoglycemic. Compounds containing oxadiazole moieties have been described as possessing anticancer or muscle relaxant activity and have been used as fluorescent whiteners. Usually, the synthesis of non-symmetrical 2,5-disubstituted 1,3,4- oxadiazoles has mainly been done by dehydratation of diacylhydrazines or oxidative cyclization of aldehyde N-acylhydrazones, but many other reagents and reaction conditions have been reported to achieve their obtainment.

Among five-membered aromatic heterocycles, 1,3,4- oxadiazoles are important class of aromatic heterocycles displaying a broad spectrum of biological activities, such as antimicrobial, anti-inflammatoy, analgesic, anticonvulsivant, anti-hypoglycemic. Compounds containing oxadiazole moieties have been described as possessing anticancer or muscle relaxant activity and have been used as fluorescent whiteners. Usually, the synthesis of non-symmetrical 2,5-disubstituted 1,3,4- oxadiazoles has mainly been done by dehydratation of diacylhydrazines or oxidative cyclization of aldehyde N-acylhydrazones, but many other reagents and reaction conditions have been reported to achieve their obtainment.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013610185416

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Como citar:

Paim, Gisele R.; Meira, Susiane C.; Pittaluga, Everton P.; Porte, Liliane M. F.; Meyer, Alexandre R.; Navarini, Jussara; Bonacorso, Helio G.; "New 1,3,4-Oxadiazolyl-pyrazolyl-Pyridine Tricyclic Scaffold Derivatives: Synthesis and Structure Assignment by NMR and DFT Calculations", p-142-142. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013610185416