Fevereiro 2015 vol. 1 num. 2 - XX Congresso Brasileiro de Engenharia Química
Artigo - Open Access.
MONODISPERSE MICROPARTICLES OBTAINED USING SPG MEMBRANE TECHNIQUE
Biodegradable particles with narrow size distribution are desirable as drug delivery systems. Monodisperse microparticles (MPs) prepared with degradable polymer for application as drug delivery system was designed. PLLA microparticles (MPs) with size around 2 and 5 µm were prepared using the SPG membrane emulsification technique. The ratio value between mean particle size and mean pore size may only kept constant once the operating conditions are optimized. Hydrophobic dye as N-(2,6-diisopropylphenyl)perylene-3,4-dicarbonacidimide (PMI) was encapsulated. The morphology was evaluated using SEM and fluorescence microscopy. PMI - labeled-microparticles represent their ability of encapsulate hydrophobic drugs. The polymer chosen exhibited enzymatic degradation. These initial results demonstrate the potencial for application as drug delivery system that requires enzyme-triggered
-  ANDERSON, J. M. and SHIVE, M. S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. v. 64, p. 72–82, 2012.
-  BYRON, P. Determinants of drug and polypeptide bioavailability from aerosols delivered to the lung. Advanced Drug Delivery Reviews, n. 5, p. 107 – 132, 1990.
-  GAUMET, M.; GURNY, R.; DELIE, F. Fluorescent biodegradable PLGA particles with narrow size distributions: preparation by means of selective centrifugation. International journal of pharmaceutics, v. 342, n. 1-2, p. 222–30, 5 set. 2007.
-  HUREAUX, J. et al. Lipid nanocapsules: ready-to-use nanovectors for the aerosol delivery of paclitaxel. European journal of pharmaceutics and biopharmaceutics, v. 73, n. 2, p. 239–46, out. 2009.
-  ITO, F.; MAKINO, K. Preparation and properties of monodispersed rifampicin-loaded poly(lactide-co-glycolide) microspheres. Colloids and surfaces. B, Biointerfaces, v. 39, n. 1-2, p. 17–21, 25 nov. 2004.
-  KLEINSTREUER, C.; ZHANG, Z.; DONOHUE, J. F. Targeted drug-aerosol delivery in the human respiratory system. Annual review of biomedical engineering, v. 10, p. 195–220, jan. 2008.
-  MA, G.; NAGAI, M.; OMI, S. Preparation of uniform poly(lactide) microspheres by employing the Shirasu Porous Glass (SPG) emulsification technique. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 153, p. 383–394, 1999.
-  NAZIR, A.; SCHROËN, K.; BOOM, R. Premix emulsification: A review. Journal of Membrane Science, v. 362, n. 1-2, p. 1–11, out. 2010.
-  OH, D. H. et al. Effect of process parameters on nanoemulsion droplet size and distribution in SPG membrane emulsification. International journal of pharmaceutics, v. 404, n. 1-2, p. 191–7, 14 fev. 2011.
-  PARK, T. G. Degradation of poly ( lactic-co-glycolic acid ) microspheres : effect of copolymer composition. Biomaterials, v. 16, n. 15, p. 1123–1130, 1995.
-  VLADISAVLJEVIĆ, G. T.; SHIMIZU, M.; NAKASHIMA, T. Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity. Journal of Membrane Science, v. 284, n. 1-2, p. 373–383, 1 nov. 2006.
-  6. ACKNOLOGMENT The authors thank the financial support from CNPq – Conselho Nacional de Desenvolvimento Científico and BMBF – Bundesministerium für Bildung und Forschung.
STEINMACHER, F. R.; MUSYANOVYCH, A.; LANDFESTER, K.; SAYER, C.; ARAUJO, P. H. H.; "MONODISPERSE MICROPARTICLES OBTAINED USING SPG MEMBRANE TECHNIQUE", p. 13286-13293 . In: Anais do XX Congresso Brasileiro de Engenharia Química - COBEQ 2014 [= Blucher Chemical Engineering Proceedings, v.1, n.2].
São Paulo: Blucher,
ISSN 2359-1757, DOI 10.5151/chemeng-cobeq2014-0268-26261-162431
últimos 30 dias | último ano | desde a publicação