MONODISPERSE MICROPARTICLES OBTAINED USING SPG MEMBRANE TECHNIQUE

MONODISPERSE MICROPARTICLES OBTAINED USING SPG MEMBRANE TECHNIQUE

STEINMACHER, F. R.; MUSYANOVYCH, A.; LANDFESTER, K.; SAYER, C.; ARAUJO, P. H. H.

Artigo:

Biodegradable particles with narrow size distribution are desirable as drug delivery systems. Monodisperse microparticles (MPs) prepared with degradable polymer for application as drug delivery system was designed. PLLA microparticles (MPs) with size around 2 and 5 µm were prepared using the SPG membrane emulsification technique. The ratio value between mean particle size and mean pore size may only kept constant once the operating conditions are optimized. Hydrophobic dye as N-(2,6-diisopropylphenyl)perylene-3,4-dicarbonacidimide (PMI) was encapsulated. The morphology was evaluated using SEM and fluorescence microscopy. PMI - labeled-microparticles represent their ability of encapsulate hydrophobic drugs. The polymer chosen exhibited enzymatic degradation. These initial results demonstrate the potencial for application as drug delivery system that requires enzyme-triggered

Biodegradable particles with narrow size distribution are desirable as drug delivery systems. Monodisperse microparticles (MPs) prepared with degradable polymer for application as drug delivery system was designed. PLLA microparticles (MPs) with size around 2 and 5 µm were prepared using the SPG membrane emulsification technique. The ratio value between mean particle size and mean pore size may only kept constant once the operating conditions are optimized. Hydrophobic dye as N-(2,6-diisopropylphenyl)perylene-3,4-dicarbonacidimide (PMI) was encapsulated. The morphology was evaluated using SEM and fluorescence microscopy. PMI - labeled-microparticles represent their ability of encapsulate hydrophobic drugs. The polymer chosen exhibited enzymatic degradation. These initial results demonstrate the potencial for application as drug delivery system that requires enzyme-triggered

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DOI: 10.5151/chemeng-cobeq2014-0268-26261-162431

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• [12] 6. ACKNOLOGMENT The authors thank the financial support from CNPq – Conselho Nacional de Desenvolvimento Científico and BMBF – Bundesministerium für Bildung und Forschung.

Como citar:

STEINMACHER, F. R.; MUSYANOVYCH, A.; LANDFESTER, K.; SAYER, C.; ARAUJO, P. H. H.; "MONODISPERSE MICROPARTICLES OBTAINED USING SPG MEMBRANE TECHNIQUE", p-13286-13293. In: Anais do XX Congresso Brasileiro de Engenharia Química - COBEQ 2014 [= Blucher Chemical Engineering Proceedings, v.1, n.2]. São Paulo: Blucher, 2015.
ISSN 23591757, DOI 10.5151/chemeng-cobeq2014-0268-26261-162431