Lipase-mediated Desymmetrization of 1,3-di-O-Benzyl-myo- Inositol

Lipase-mediated Desymmetrization of 1,3-di-O-Benzyl-myo- Inositol

Pais, Karla C.; Manoel, Evelin A.; Freire, Denise M. G.; Simas, Alessandro B. C.

Abstract:

The phosphorylated myo-inositols play key roles in fundamental biological phenomena such as cellular signal transduction. Notwithstanding the efficiency and practicality of catalytic reactions, most syntheses of chiral inositols have relied on chiral derivatizations. In this context, few reports in the literature have explored lipases for desymmetrysations and kinetic resolutions of myo-inositol derivatives. In this work, we report the enzymatic desymmetrization of 1,3-di-O-benzyl-myo-inositol 1 (Scheme 2).

The phosphorylated myo-inositols play key roles in fundamental biological phenomena such as cellular signal transduction. Notwithstanding the efficiency and practicality of catalytic reactions, most syntheses of chiral inositols have relied on chiral derivatizations. In this context, few reports in the literature have explored lipases for desymmetrysations and kinetic resolutions of myo-inositol derivatives. In this work, we report the enzymatic desymmetrization of 1,3-di-O-benzyl-myo-inositol 1 (Scheme 2).

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915195333

Referências bibliográficas

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Como citar:

Pais, Karla C.; Manoel, Evelin A.; Freire, Denise M. G.; Simas, Alessandro B. C.; "Lipase-mediated Desymmetrization of 1,3-di-O-Benzyl-myo- Inositol", p-268-268. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915195333