Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

Pastre, Julio C.; Murray, Philip R. D.; Browne, Duncan L.; Pilli1, Ronaldo A.; Ley, Steven V.

Abstract:

Continuous-flow techniques can often provide better mixing and heat transfer, precise control over concentrated or hazardous reaction streams, reduced solvent waste and synthetic shortcuts. Moreover, the rapid process optimization of synthetic steps on a small scale, combined with the telescoping of steps together in a continuous mode, enables more elaborate multistep sequences to be performed, leading directly to drug molecules or even natural products. Bearing this in mind, we aimed at developing a continuous flow process for the synthesis of goniothalamin (3), which presents potent in vivo antitumor activity.

Continuous-flow techniques can often provide better mixing and heat transfer, precise control over concentrated or hazardous reaction streams, reduced solvent waste and synthetic shortcuts. Moreover, the rapid process optimization of synthetic steps on a small scale, combined with the telescoping of steps together in a continuous mode, enables more elaborate multistep sequences to be performed, leading directly to drug molecules or even natural products. Bearing this in mind, we aimed at developing a continuous flow process for the synthesis of goniothalamin (3), which presents potent in vivo antitumor activity.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013914162426

Referências bibliográficas

• [1] 1 I. R. Baxendale, J. Chem. Technol. Biotechnol. 2013, 88, 519.
• [2] 2 Pastre, J. C.; Browne, D. L.; Ley, S. V. Chem. Soc. Rev. 2013, DOI: 10.1039/c3cs60246j.
• [3] 3 Vendramini-Costa, D.; de Castro, I. D. B.; Ruiz, A. L. T.; Marquissolo, C. Pilli, R. A.; de Carvalho, J. E. Bioorg. Med. Chem. 2010, 18, 6742.
• [4] 4 Dimer was formed in ca. 8%.

Como citar:

Pastre, Julio C.; Murray, Philip R. D.; Browne, Duncan L.; Pilli1, Ronaldo A.; Ley, Steven V.; "Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin", p-243-243. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013914162426