Highly regioselective epoxide hydrogenolysis aiming at the bulgecinine synthesis

Highly regioselective epoxide hydrogenolysis aiming at the bulgecinine synthesis

Martinez, Pablo David G.; Correia, Carlos Roque D.

Abstract:

Bulgecins are bacterial metabolites that interfere with the cell-wall synthesis of Gramnegative bacteria when used in combination with - lactams antibiotics. These compounds consist in a glucosamine linked to the non-proteinogenic amino acid 1 called bulgecinine. The biological acitivity of bulgecins is unique as they operate inhibiting specific enzymes not present in mammals. This feature makes bulgecinine an important target to synthesize, as well as a template to find biologically active molecules more potent than the natural entity.

Bulgecins are bacterial metabolites that interfere with the cell-wall synthesis of Gramnegative bacteria when used in combination with - lactams antibiotics. These compounds consist in a glucosamine linked to the non-proteinogenic amino acid 1 called bulgecinine. The biological acitivity of bulgecins is unique as they operate inhibiting specific enzymes not present in mammals. This feature makes bulgecinine an important target to synthesize, as well as a template to find biologically active molecules more potent than the natural entity.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013819125138

Referências bibliográficas

• [1] 1 Imada, A.; Kintaka, K.; Nakao, M.; Shinagawa, S. J. Antibiot., 1982, 35,
• [2] 1400.
• [3] 2 Moro, A. V.; Rodrigues dos Santos, M.; Correia, C. R. D. Eur. J. Org.
• [4] Chem 2011, 2011, 7259

Como citar:

Martinez, Pablo David G.; Correia, Carlos Roque D.; "Highly regioselective epoxide hydrogenolysis aiming at the bulgecinine synthesis", p-169-169. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013819125138