General pathways for obtainment of halo-containing 1,8- naphthyridines,1,8-naphthyridin-2(1H)-ones and their derivatives

General pathways for obtainment of halo-containing 1,8- naphthyridines,1,8-naphthyridin-2(1H)-ones and their derivatives

Andrighetto, Rosália; Bonacorso, Helio G.; Stefanello, Felipe S.; Martins, Marcos A. P.; Zanatta, Nilo

Abstract:

The 1,8-naphthyridine core is a versatile template for drug discovery and deserves special attention because of their interesting complexation properties and medical uses. On the other hand, has been recognized that attachment of a trifluoromethyl group into heterocycles can be used to modulate the physical, chemical and biological properties. Furthermore, there are many chlorinated heterocycles that have important pharmacological activities such as example Clomacran, Chloroquine and Amodiaquine. In addition, reactions of chlorinated heterocycles with heteraromatic amines can attract specific interest to provide a synthetic route to aza-heterocycles. We have been engaged to establish protocols for regioselective cyclocondensation reactions of the type C-C and / or C-N from of a variety of β-alkoxyvinyl trifluoromethyl ketones (1) with 2,6-diaminopyridine (2,6-DAP) as well derivatization reactions from of the free amino group.

The 1,8-naphthyridine core is a versatile template for drug discovery and deserves special attention because of their interesting complexation properties and medical uses. On the other hand, has been recognized that attachment of a trifluoromethyl group into heterocycles can be used to modulate the physical, chemical and biological properties. Furthermore, there are many chlorinated heterocycles that have important pharmacological activities such as example Clomacran, Chloroquine and Amodiaquine. In addition, reactions of chlorinated heterocycles with heteraromatic amines can attract specific interest to provide a synthetic route to aza-heterocycles. We have been engaged to establish protocols for regioselective cyclocondensation reactions of the type C-C and / or C-N from of a variety of β-alkoxyvinyl trifluoromethyl ketones (1) with 2,6-diaminopyridine (2,6-DAP) as well derivatization reactions from of the free amino group.

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DOI: 10.5151/chempro-15bmos-BMOS2013_201368142558

Referências bibliográficas

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Como citar:

Andrighetto, Rosália; Bonacorso, Helio G.; Stefanello, Felipe S.; Martins, Marcos A. P.; Zanatta, Nilo; "General pathways for obtainment of halo-containing 1,8- naphthyridines,1,8-naphthyridin-2(1H)-ones and their derivatives", p-36-36. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201368142558