Formal γ-alkynylation of ketones via Pd-catalyzed C-C cleavage

Formal γ-alkynylation of ketones via Pd-catalyzed C-C cleavage

Ziadi, Asraa; Correa, Arkaitz; Martin, Rubén

Abstract:

An efficient Pd-catalyzed ketone γ-arylation via β- carbon elimination with aryl chlorides, was recently developed in our group (Figure 1). Encouraged by these results, and due to the prevalence of versatile alkyne motifs in numerous bioactive compounds and electronic materials, we set out to investigate the γ- alkynylation of cyclobutanols (Figure 1).

An efficient Pd-catalyzed ketone γ-arylation via β- carbon elimination with aryl chlorides, was recently developed in our group (Figure 1). Encouraged by these results, and due to the prevalence of versatile alkyne motifs in numerous bioactive compounds and electronic materials, we set out to investigate the γ- alkynylation of cyclobutanols (Figure 1).

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DOI: 10.5151/chempro-15bmos-BMOS2013_201361775955

Referências bibliográficas

• [1] 1For selected reviews, see: (a) Seiser, T.; Saget, T.; Tran, D. N.; Cramer, N. Angew. Chem., Int. Ed. 2011, 7740. (b) Murakami, M.; Makino, M.; Ashida, S.; Matsuda, T. Bull. Chem. Soc. Jpn. 2006, 1315. (c) Aïsa, C. Synthesis 2011, 1315.
• [2] 2 Ziadi, A.; Martin, R., Org. Lett. 2012, 1266.
• [3] 3 Ziadi, A.; Correa, A.; Martin, R., Chem. Comm. 2013, 4286.

Como citar:

Ziadi, Asraa; Correa, Arkaitz; Martin, Rubén; "Formal γ-alkynylation of ketones via Pd-catalyzed C-C cleavage", p-34-34. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201361775955