Efficient synthesis via molecular sieve of 3-(pyrimidin-2yl)- thiazolidinones

Efficient synthesis via molecular sieve of 3-(pyrimidin-2yl)- thiazolidinones

Ribeiro; C.S.; Jr, Campos; J.C.; Bierhals; M.P.; Freitag; R.A.; Cunico; W.; Siqueira; G.M.

Abstract:

Several methods for the synthesis of thiazolidin-4- ones are described in the literature. The most often used involves three components: a primary amine, a carbonyl compound and mercaptoacetic acid using azeotropic distillation with Dean-Stark trap, for the water removal, is the most common approach. Besides, other protocols were developed by using dehydrating agents among these Na2SO4, molecular sieves, DCC and others, with the purpose to improve the yield of the products. The aim of this study was explore the application of molecular sieves in compare with Dean-Satrk trap, as dehydrating agents in the synthesis of 3- (pyrimidin-2-yl)-thiazolidinones.

Several methods for the synthesis of thiazolidin-4- ones are described in the literature. The most often used involves three components: a primary amine, a carbonyl compound and mercaptoacetic acid using azeotropic distillation with Dean-Stark trap, for the water removal, is the most common approach. Besides, other protocols were developed by using dehydrating agents among these Na2SO4, molecular sieves, DCC and others, with the purpose to improve the yield of the products. The aim of this study was explore the application of molecular sieves in compare with Dean-Satrk trap, as dehydrating agents in the synthesis of 3- (pyrimidin-2-yl)-thiazolidinones.

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DOI: 10.5151/chempro-15bmos-BMOS2013_20139160210

Referências bibliográficas

• [1] 1. Jain, A. K.; Vaidya, A.; Ravichandran, V.; Kashaw, S. K.; Agrawal, R. K., Bioorganic And Medicinal Chemistry 2012, 20
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• [3] 2. Prasad, D.; Nath, M., J. Heterocycl. Chem. 2012, 49 (3), 628-633.
• [4] 3. Gouvea, D. P.; Bareno, V. D. O.; Bosenbecker, J.; Drawanz, B. B.; Neuenfeldt, P. D.; Siqueira, G. M.; Cunico, W., Ultrason. Sonochem. 2012, 19 (6), 1127-1131. Campos, J. C.; Gouvêa, D. P.; Ribeiro, C. d. S. et al, J Biochem. Mol. Tox. 2013, 27 (9), 445-450.

Como citar:

Ribeiro, ; C.S., ; Jr, Campos; J.C., ; Bierhals, ; M.P., ; Freitag, ; R.A., ; Cunico, ; W., ; Siqueira, ; G.M., ; "Efficient synthesis via molecular sieve of 3-(pyrimidin-2yl)- thiazolidinones", p-14-14. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_20139160210