Directed Metalation of Aromatic Aldimines Using Li/Mg-TMP Amides

Directed Metalation of Aromatic Aldimines Using Li/Mg-TMP Amides

Cavalcante Silva, S.; Batista; H., J.; F., Moraes; Pereira; A., N. de; Clososki; G.C.

Abstract:

It has been reported in literature that metal based TMP bases are important reagents for the deprotonation of unsaturated substrates. In this work we describe our results on the directed metalation of N-cyclohexyl aromatic aldimines with Li/Mg TMP bases. Aldimines have attracted great attention by displaying a wide variety of biological activities. In addition, aldimines can be metalated and trapped with electrophiles and the resulting products can subsequently be converted to the corresponding benzaldehyde derivatives.

It has been reported in literature that metal based TMP bases are important reagents for the deprotonation of unsaturated substrates. In this work we describe our results on the directed metalation of N-cyclohexyl aromatic aldimines with Li/Mg TMP bases. Aldimines have attracted great attention by displaying a wide variety of biological activities. In addition, aldimines can be metalated and trapped with electrophiles and the resulting products can subsequently be converted to the corresponding benzaldehyde derivatives.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013926134127

Referências bibliográficas

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• [4] 3 Flippin, L. A.; Muchowski, J .M.; Carter, D. M. J Org. Chem. 1993, 58,
• [5] 2463

Como citar:

Cavalcante Silva, S.; Batista, ; H., J.; F., Moraes; Pereira, ; A., N. de; Clososki, ; G.C., ; "Directed Metalation of Aromatic Aldimines Using Li/Mg-TMP Amides", p-290-290. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013926134127