Coumarins from Free ortho-Hydroxy Cinnamates by Heck- Matsuda Arylations and their Application in the Total Synthesis of (R)-Tolterodine

Coumarins from Free ortho-Hydroxy Cinnamates by Heck- Matsuda Arylations and their Application in the Total Synthesis of (R)-Tolterodine

Barancelli, Daniela Aline; Jr., Airton G. Salles; Taylor, Jason G.; Correia, Carlos Roque D.

Abstract:

Arylation methods are among the most important reaction types in organic synthesis. In recent years, our group and others have been exploring the palladium-catalyzed coupling of arenediazonium salts to olefins (Heck-Matsuda reaction) as a convenient method to obtain arylated and diarylated compounds of biological and medicinal interest. In this context, coumarins might be considered representative diarylated species of great interest due to their biological properties.

Arylation methods are among the most important reaction types in organic synthesis. In recent years, our group and others have been exploring the palladium-catalyzed coupling of arenediazonium salts to olefins (Heck-Matsuda reaction) as a convenient method to obtain arylated and diarylated compounds of biological and medicinal interest. In this context, coumarins might be considered representative diarylated species of great interest due to their biological properties.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013816201342

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Como citar:

Barancelli, Daniela Aline; Jr., Airton G. Salles; Taylor, Jason G.; Correia, Carlos Roque D.; "Coumarins from Free ortho-Hydroxy Cinnamates by Heck- Matsuda Arylations and their Application in the Total Synthesis of (R)-Tolterodine", p-160-160. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013816201342