Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

Murray, Philip R. D.; Browne, Duncan L.; Pastre, Julio C.; Ley, Steven V.

Abstract:

Flow chemistry offers potential utility to synthesis with organometallic reagents. The accurate temperature control of the potentially exothermic processes, the rapid and stoichiometric mixing of organometallic reagents and substrates, and the safe handling of the reactive components in a fully contained system are all examples of the potential benefits over traditional batch manipulations. However, organometallic reagents pose many technical hurdles with regard to continuous processing, not the least of which is the ability to pump these important and powerful reagents in a truly continuous fashion.

Flow chemistry offers potential utility to synthesis with organometallic reagents. The accurate temperature control of the potentially exothermic processes, the rapid and stoichiometric mixing of organometallic reagents and substrates, and the safe handling of the reactive components in a fully contained system are all examples of the potential benefits over traditional batch manipulations. However, organometallic reagents pose many technical hurdles with regard to continuous processing, not the least of which is the ability to pump these important and powerful reagents in a truly continuous fashion.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013914162643

Referências bibliográficas

• [1] 1 Flow chemistry equipment website: http://www.vapourtec.co.uk.
• [2] 2 Murray, P.; Browne, D. L.; Pastre, J. C.; Butters, C.; Guthrie, D.; Ley, S.
• [3] V. Org. Process Res. Dev. 2013, DOI: 10.1021/op4001548.

Como citar:

Murray, Philip R. D.; Browne, Duncan L.; Pastre, Julio C.; Ley, Steven V.; "Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen", p-244-244. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013914162643