Blucher Chemistry Proceedings

Dezembro 2013, vol.1, num.2 - Brazilian Meeting on Organic Synthesis 2013
Abstract - Open Access Idioma principal | Segundo principal

Chemoenzymatic Enantiospecific Synthesis of a Fluorinated myo-Inositol Analogue

Chemoenzymatic Enantiospecific Synthesis of a Fluorinated myo-Inositol Analogue

Silva, Angelo Amaro T. da; Cunha, Aline G.; Manoel, Evelin A.; Freire, Denise Maria. G.; Simas, Alessandro B. C.

Abstract:

Inositol derivatives play important roles in biological systems. D-myo-Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] (1) is a major second messenger associated with many cellular signaling processes (Figure 1). Among other analogs, fluorinated inositols have been studied as biological probes for pathways involving cyclitol biotransformations. Herein, we describe an enantiospecific synthesis of 1L-(−)-4-deoxy-4-fluor-myo-inositol [(−)-2] via an enzymatic kinetic resolution approach (Figure 1).

Inositol derivatives play important roles in biological systems. D-myo-Inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] (1) is a major second messenger associated with many cellular signaling processes (Figure 1). Among other analogs, fluorinated inositols have been studied as biological probes for pathways involving cyclitol biotransformations. Herein, we describe an enantiospecific synthesis of 1L-(−)-4-deoxy-4-fluor-myo-inositol [(−)-2] via an enzymatic kinetic resolution approach (Figure 1).

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915174810

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Como citar:

Silva, Angelo Amaro T. da; Cunha, Aline G.; Manoel, Evelin A.; Freire, Denise Maria. G.; Simas, Alessandro B. C.; "Chemoenzymatic Enantiospecific Synthesis of a Fluorinated myo-Inositol Analogue", p-259-259. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915174810

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