Fevereiro 2015 vol. 1 num. 2 - XX Congresso Brasileiro de Engenharia Química

Artigo - Open Access.

Idioma principal




Grape pomace presents a high content of phenolic compounds, which are associated with health benefits. The encapsulation of natural extracts using polymers is important in order to facilitate the product handling and improves its stability.The objective of this work was to apply the Supercritical Anti-Solvent (SAS) process to encapsulate grape pomace extract in poly(lactic-co-glycolic) acid (PLGA). The grape pomace extract was obtained by Soxhlet with ethanol, and the encapsulation process applied ethyl acetate as primary solvent and 99.9% pure CO2 as anti-solvent. Briefly, the process initiates by the adjustment of operational parameters, followed by the introduction of the extract solution simultaneously with the supercritical CO2. The process was performed using CO2 flow rate of 1kg/h and at different conditions of pressure (80-140bar) and temperature (35-45



DOI: 10.5151/chemeng-cobeq2014-1972-16601-138953

Referências bibliográficas
  • [1] ADAMI, R.; REVERCHON, E.; JARVENPAA, E.; HUOPALAHTI, R. Supercritical AntiSolvent micronization of nalmefene HCl on laboratory and pilot scale. Powder Techn.v. 182, p. 105-112, 2008.
  • [2] AOAC (Association of Official Analytical Chemists). Official methods of analysis. ed. 14.
  • [3] Washington, D. C. 2005.
  • [4] CHATTOPADHYAY, P.; GUPTA, R.B. Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer.AIChE J. v. 48, p. 235-244, 2002.
  • [5] COCERO, M.J.; FERRERO, S. Crystallization of beta-carotene by a GAS process in batch. Effect of operating conditions.J. Supercr. Fluids.v. 22, p. 237-241,2002.
  • [6] DEBENEDETTI, P.G.; TOM, J.W.; YEO, S.D. Rapid expansion of supercritical solutions (RESS): fundamentals and applications.Fluid Phase Eq.v. 82, p. 311-318, 1993.
  • [7] -0.500.511.522.5-3 17 37 57 77 97Heat fllow (oC/min)Sample temperature (oC)40oC, 110 bar, 1kg_CO2/h, 1mL_solvent/min, 4mg_extract/mL40oC, 140bar, 1kg_CO2/h, 1 mL_solvent/min, 4mg_extract/mL40oC, 80bar, 1kg_CO2/h, 1mL_solvent/min, 4mg_extract/mL35oC, 110bar, 1kg_CO2/h, 1mL_solvent/min, 4mg_extract/mL40oC, 110bar, 1kg_CO2/h, 1mL_solvent/min, 2mg_extract/mL45oC, 110bar, 1kg_CO2/h, 1mL_solvent/min, 4mg_extract/mL40oC, 110bar, 1kg_CO2/h, 1 mL_solvent/min, 6mg_extract/mL40oC, 110 bar, 1kg_CO2/h, 2mL_solvent/min, 4mg_extract/mLÁrea temática: Engenharia das Separações e Termodinâmica 7FILIP, V.; PLOCKOVÁ, M.; SMIDRKAL, J.; PCICKOVÁ, Z.; MELZOCH, K.; SCHMIDT, S. Resveratrol and Its Antioxidant and Antimicrobial Effectiveness. Food Chem., v. 83/4, p. 585-593, 2003.
  • [8] GALLAGHER, P.M.; COFFEY, M.P.; KRUKONIS, V.J. Gas anti-solvent recrystallization of RDX: Formation of ultra-fine particles of a difficult-to-comminute explosive. J. Supercr. Fluids. v. 5, p. 130-142, 1992.
  • [9] HIGUERA-CIAPARA, I.; FELIX-VALENZUELA, L.; GOYCOOLEA, F. M.; ARGÜELLES-MONAL, W. Microencapsulation of astaxanthin in a chitosan matrix. Carbohydrate Polym. v. 56, p. 41-45, 2004.
  • [10] JUNG, J.; PERRUT, M. Particle design using supercritical fluids: Literature and patent survey. J. Supercr. Fluids. v. 20, p. 179-219, 2001.
  • [11] MARTÍN, A.; MATTEA, F.; GUTIÉRREZ, L.; MIGUEL, F.; COCERO, M. J. Co-precipitation of carotenoids and bio-polymers with the supercritical anti-solvent process. J. Supercr. Fluids. v. 41, p. 138–147, 2007.
  • [12] MCCLAIN, R.M.; BAUSCH, J. Summary of safety studies conducted with synthetic lycopene. Regul. Toxicol. Pharmacol. v. 37, p. 274-280, 2003.
  • [13] MEZZOMO, N.; FERREIRA, S. R. S. Supercritical Anti-Solvent Precipitation of Sodium Ibuprofen. In: III Iberoamerican Conference on Supercritical Fluids, 20
  • [14] MIGUEL, F.; MARTÍN, Á.;GAMSE, T.; COCERO, M.J. Supercritical anti solvent precipitation of lycopene. Effect of the operating parameters. J. Supercr. Fluids. v. 36, p. 225-231, 2006.
  • [15] MIGUEL, F.; MARTÍN, A.; MATTEA, F.; COCERO, M.J. Precipitation of lutein and co-precipitation of lutein and poly-lactic acid with the supercritical anti-solvent process. Chem. Eng. Proc.: Process Intensif. v. 47/9-10, p. 1594-1602, 2008.
  • [16] NEGRO, C.; TOMMASI, L.; MICELI, A. Phenolic Com- pounds and Antioxidant Activity from Red Grape Marc Extracts. Biores. Techn. v. 87/1, p. 41-44, 2003.
  • [17] PINELO, M.; ARNOUS, A.; MEYER, A. S. Upgrading of Grape Skins: Significance of Plant Cell-Wall Structural Components and Extraction Techniques for Phenol Re- lease. Trends in Food Sc. Andamp;Techn.,v. 17/11, p. 579-590, 2006.
  • [18] THIES, J.; lled production of biodegradable microparticles with supercritical gases. Europ. J. Pharm. Bioph. v. 45, p. 67-74, 1998.
  • [19] VARONA, S.; KARETH, S.; MARTÍN, Á.; COCERO, M.J. Formulation of lavandin essential oil with biopolymers by PGSS for application as biocide in ecological agriculture. J. Supercr. Fluids. v. 54, p. 369-374, 2010.
  • [20] YEO, S.D.; KIRAN, E. Formation of polymer particles with supercritical fluids: A review. J. Supercr. Fluids.v. 34, p. 287-308, 2005.
  • [21] WEIDNER, E.; KNEZ, Z.; NOVAK, Z. Int. Pat. Publ. WO 95/21688,1995.
Como citar:

MEZZOMO, N.; OLIVEIRA, D. A.; COMIM, S. R. R.; FERREIRA, S. R. S.; "CHARACTERISTICS OF GRAPE POMACE EXTRACT AND PLGA PARTICLES PRODUCED BY SAS PROCESS", p. 16288-16295 . In: Anais do XX Congresso Brasileiro de Engenharia Química - COBEQ 2014 [= Blucher Chemical Engineering Proceedings, v.1, n.2]. São Paulo: Blucher, 2015.
ISSN 2359-1757, DOI 10.5151/chemeng-cobeq2014-1972-16601-138953

últimos 30 dias | último ano | desde a publicação