Benzothiadiazole-triazole-linked biologically active lapachone derivatives: Antitumoral activity and bioimaging application

Benzothiadiazole-triazole-linked biologically active lapachone derivatives: Antitumoral activity and bioimaging application

Cruz, Eduardo H. G. da; Carvalho, Pedro H. P. R.; Silva, Diego A. C. da; Diogo, Emilay B. T.; Pessoa, Claudia; Coêlho, Bruno; Neto, Brenno A. D.; Júnior, Eufrânio N. da Silva

Abstract:

Lapachone derivatives are well known for their notable efficiency against many cancer cell lines. These compounds are virtually non-fluorescent, therefore a visual tracking to help in the elucidation of their mechanisms and targets inside the cell are a hard task. In order to surpass this major drawback, a naphthoquinone derivative were joint together with a BTD (2,1,3-benzothiadiazole) core, already known for its photoluminescent properties, affording a fluorescent compound that could be tracked inside the cell (Scheme 1).

Lapachone derivatives are well known for their notable efficiency against many cancer cell lines. These compounds are virtually non-fluorescent, therefore a visual tracking to help in the elucidation of their mechanisms and targets inside the cell are a hard task. In order to surpass this major drawback, a naphthoquinone derivative were joint together with a BTD (2,1,3-benzothiadiazole) core, already known for its photoluminescent properties, affording a fluorescent compound that could be tracked inside the cell (Scheme 1).

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DOI: 10.5151/chempro-15bmos-BMOS2013_201310113240

Referências bibliográficas

• [1] 1Oliveira, L. G.; Silva, M. M.; Paula, F. C. S.; Pereira-Maia, E. C.; Donnici, C. L.; Simone, C. A.; Frézard, F.; Silva Júnior, E. N.; Demicheli, C. Molecules. 2011, 16, 10314.
• [2] 2Neto, B. A. D.; Lapis, A. A. M.; da Silva Júnior, E. N.; Dupont, J. Eur. J. Org. Chem. 2013, 228.
• [3] 3Rostovtsev, V. V.; Green, G. L.; Fokin, V. V.; Sharpless, K. B.; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.

Como citar:

Cruz, Eduardo H. G. da; Carvalho, Pedro H. P. R.; Silva, Diego A. C. da; Diogo, Emilay B. T.; Pessoa, Claudia; Coêlho, Bruno; Neto, Brenno A. D.; Júnior, Eufrânio N. da Silva; "Benzothiadiazole-triazole-linked biologically active lapachone derivatives: Antitumoral activity and bioimaging application", p-28-28. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201310113240