Asymmetric synthesis of pyranocumarins under greener conditions

Asymmetric synthesis of pyranocumarins under greener conditions

Monteiro, J. L.; Torre, A. F.; Paixão, M. P.; Corrêa, A. G.

Abstract:

Coumarins, in particular pyranocoumarins, are known as potent inhibitors of acetylcholinesterase enzyme primarily responsible for neurodegenerative disorders such as Alzheimer's disease. Rueping et al. reported the asymmetric synthesis of pyranocoumarins using the Jørgensen–Hayashi organocatalyst (20 mol%) in dichloromethane at 10 oC for 48-96 h. The study and development of new methodologies for faster, greener, and more selective synthesis of bioactive compounds is of great interest. This study aims to explore the asymmetric synthesis of pyranocoumarins under eco-friendly reaction conditions.

Coumarins, in particular pyranocoumarins, are known as potent inhibitors of acetylcholinesterase enzyme primarily responsible for neurodegenerative disorders such as Alzheimer's disease. Rueping et al. reported the asymmetric synthesis of pyranocoumarins using the Jørgensen–Hayashi organocatalyst (20 mol%) in dichloromethane at 10 oC for 48-96 h. The study and development of new methodologies for faster, greener, and more selective synthesis of bioactive compounds is of great interest. This study aims to explore the asymmetric synthesis of pyranocoumarins under eco-friendly reaction conditions.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013101414540

Referências bibliográficas

• [1] 1 Silva, J. I.; Moraes, M. C.; Vieira, L. C. C.; Correa, A. G.; Cass, Q. B.; Cardoso, C. L. J. Pharmaceut. Biomed. Anal. 2013, 73, 44. Han, J.; Lee, S.; Kim, H. M.; Shin, B. Bull. Korean Chem. Soc. 2008, 29, 1572.
• [2] 2 Rueping, M.; Merino, E.; Sugoino, E.; Adv. Synth. Catal. 2008, 350, 2127.
• [3] 3 Yang, G.; Wu, J.; Zhan, C.; Huang, X.; Zhu, X.; Wang, L.; Zhao, P. J.Am. Chem. Soc. 2010, 132, 185.
• [4] 4 Deobald, A. M.; Corrêa, A. G; Rivera, D. G; Paixão, M. P. Org. Biomol. Chem. 2012, 10, 7681.

Como citar:

Monteiro, J. L.; Torre, A. F.; Paixão, M. P.; Corrêa, A. G.; "Asymmetric synthesis of pyranocumarins under greener conditions", p-130-130. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013101414540