Assembly Line Synthesis

Assembly Line Synthesis

Aggarwal, Varinder

Abstract:

In this lecture I will present our work on the reactions of primary and secondary lithiatd carbamates with boranes and boronic esters. These reactions furnish homologated boronic esters with high levels of stereocontrol. I will show how we use this chemistry to make complex natural and unnatural products in a single operation. I will also discuss our recent methodology for the synthesis of tertiary boronic esters and how such intermediates can be used in further stereospecific transformations. Finally, I will also describe a new method for the stereospecific cross-coupling of secondary and tertiary chiral boronic esters with electron rich aryl halides.

In this lecture I will present our work on the reactions of primary and secondary lithiatd carbamates with boranes and boronic esters. These reactions furnish homologated boronic esters with high levels of stereocontrol. I will show how we use this chemistry to make complex natural and unnatural products in a single operation. I will also discuss our recent methodology for the synthesis of tertiary boronic esters and how such intermediates can be used in further stereospecific transformations. Finally, I will also describe a new method for the stereospecific cross-coupling of secondary and tertiary chiral boronic esters with electron rich aryl halides.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-2-Aggarwal_Speech_15th_BMOS-1-vka

Referências bibliográficas

• [1] 1 J. L. Stymiest, G. Dutheuil, A. Mahmood, V. K. Aggarwal, Angew. Chem. Int. Ed., 2007, 46, 7491-7494.
• [2] 2 G. Dutheuil, M. P. Webster, V. K. Aggarwal, Angew. Chem. Int. Ed., 2009, 48, 6317-6319.
• [3] 3J. L. Stymiest, V. Bagutski, R. M. French, V. K. Aggarwal, Nature, 2008, 456, 778-782; R. Larouche-Gauthier, T G. Elford, V. K. Aggarwal, J. Am. Chem. Soc., 2011, 133, 16794-16797; T. G. Elford, S. Nave, R. P. Sonawane, V. K. Aggarwal, J. Am. Chem. Soc., 2011, 133, 16798-16801; R. P. Sonawane, V. Jheengut, C. Rabalakos, R. Larouche-Gauthier, H. K. Scott, V. K. Aggarwal, Angew. Chem. Int. Ed., 2011, 50, 3760-3763.
• [4] 4 A. Bonet, M. Odachowski, S. Essafi, D. Leonori, J. Harvey, V. K. Aggarwal, manuscript submitted.

Como citar:

Aggarwal, Varinder; "Assembly Line Synthesis", p-317-317. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-2-Aggarwal_Speech_15th_BMOS-1-vka