Abstract:

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. This type of heteroaromatic skeleton can be prepared using different approaches. Recently Morita-Baylis- Hillman adducts were used as building block for the synthesis of indolizidinic unity. However, applications of these molecules remain almost unexplored. In this communication, we disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts.