An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts

An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts

Teodoro, Bruno V. M.; Correia, José Tiago M.; Coelho, Fernando

Abstract:

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. This type of heteroaromatic skeleton can be prepared using different approaches. Recently Morita-Baylis- Hillman adducts were used as building block for the synthesis of indolizidinic unity. However, applications of these molecules remain almost unexplored. In this communication, we disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts.

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. This type of heteroaromatic skeleton can be prepared using different approaches. Recently Morita-Baylis- Hillman adducts were used as building block for the synthesis of indolizidinic unity. However, applications of these molecules remain almost unexplored. In this communication, we disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201310100158

Referências bibliográficas

• [1] 1Gadad, A. K.; Mahajanshetti, C. S.; Nimbalkar, S.; Raichurkar, A. Eur. J. Med. Chem. 2000, 35, 853.
• [2] 2 Coelho, F.; Almeida, W. P.; Mateus, C. R.; Feltrin, M.; Costa, A. M. Tetrahedron 2001, 57, 6901.
• [3] 3 Rodrigues Jr., M. T.; Gomes, J. C.; Smith, J.; Coelho, F. Tetrahedron Lett. 2010, 51, 4988.

Como citar:

Teodoro, Bruno V. M.; Correia, José Tiago M.; Coelho, Fernando; "An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts", p-26-26. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201310100158